Azido-PEG5-alcohol MedChemExpress (MCE)

Product Name	14-Azido-3,6,9,12-tetraoxatetradecanol
Synonyms	N3-PEG5-OH;azido-PEG5-OH;1-Azidohexaethylene Glycol;14-Azido-3,6,9,12-tetraoxatetradecanol;14-Azido-3,6,9,12-tetraoxatetradecan-1-ol;14-Azido-3,6,9,12-tetraoxa-1-tetradecanol
CAS	86770-68-5
EINECS
Chemical Formula	C12H25N3O7
Molecular Weight	323.3428
inchi
Package	100 mg;250 mg;1 g;5 g;10 g
Price	Email to quote
Descriptions	Azido-PEG5-alcohol Azido-PEG5-alcohol MedChemExpress (MCE) HY-130211 86770-68-5 97.0% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Azido-PEG5-alcohol Azido-PEG5-alcohol MedChemExpress (MCE) HY-130211 86770-68-5 97.0% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Azido-PEG5-alcohol is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG5-alcohol is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG5-alcohol is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. PEGs Non-cleavable Linker \| \| \| \| \| \| \| \| \| \| [1]. Zhang FL, et al. Molecular-target-based anticancer photosensitizer: synthesis and in vitro photodynamic activity of erlotinib-zinc(II) phthalocyanine conjugates. ChemMedChem. 2015 Feb 10(2):312-20. [Content Brief] [2]. Nan JI, et al. Mertk degraders and uses thereof. WO2020010210A1.
Last Update	2025-04-01 14:45:47

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