N3-PEG3-CH2CH2-Boc MedChemExpress (MCE)

Product Name	tert-butyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate
Synonyms	N3-PEG3-tBu Azido-PEG3-COOtBu N3-PEG3-CH2CH2COOtBu N3-?PEG3-?t-?butyl ester tert-butyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate tert-Butyl 3-(2-(2-(2-azidoethoxyl)ethoxy)ethoxy)propanoate Synonyms N3-PEG3-tBu Azido-PEG3-COOtBu N3-PEG3-CH2CH2COOtBu N3-?PEG3-?t-?butyl ester tert-butyl 3-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)propanoate tert-Butyl 3-(2-(2-(2-azidoethoxyl)ethoxy)ethoxy)propanoate 3-[2-[2-(2-Azidoethoxy)ethoxy]ethoxy]propanoic acid 1,1-dimethylethyl ester
CAS	252881-73-5
EINECS
Chemical Formula	C13H25N3O5
Molecular Weight	303.3547
inchi
Package	50 mg;100 mg;250 mg;1 g;5 g
Price	Email to quote
Descriptions	N3-PEG3-CH2CH2-Boc N3-PEG3-CH2CH2-Boc MedChemExpress (MCE) HY-42489 252881-73-5 98.0% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions N3-PEG3-CH2CH2-Boc N3-PEG3-CH2CH2-Boc MedChemExpress (MCE) HY-42489 252881-73-5 98.0% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. N3-PEG3-CH2CH2-Boc is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N3-PEG3-CH2CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. N3-PEG3-CH2CH2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. PEGs Alkyl/ether Cleavable Linker \| \| \| \| \| \| \| \| \| \| [1]. Yongxin Robert ZHAO, et al. Conjugation linkers, cell binding molecule-drug conjugates containing the likers, methods of making and uses such conjugates with the linkers. WO2018086139A1. [2]. Peng L, et al. Identification of New Small-Molecule Inducers of Estrogen-related Receptor α (ERRα) Degradation. ACS Med Chem Lett. 2019 Apr 12 10(5):767-772. [Content Brief]
Supplier Website	https://www.medchemexpress.com/n3-peg3-ch2ch2-boc.html
Last Update	2025-05-21 16:50:25

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