Azido-PEG4-CH2-Boc MedChemExpress (MCE)

Product Name	Azido-PEG4-CH2-Boc
Synonyms	Azido-PEG4-CH2-Boc;Azido-PEG4-CH2COOtBu;Azido-PEG4-t-butyl acetate;TERT-BUTYL 14-AZIDO-3,6,9,12-TETRAOXATETRADECANOATE
CAS	864681-04-9
EINECS
Chemical Formula	C14H27N3O6
Molecular Weight	333.38068
inchi
Package	100 mg;250 mg;500 mg;1 g;5 g;10 g
Price	Email to quote
Descriptions	Azido-PEG4-CH2-Boc Azido-PEG4-CH2-Boc MedChemExpress (MCE) HY-42618 864681-04-9 97.0% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Azido-PEG4-CH2-Boc Azido-PEG4-CH2-Boc MedChemExpress (MCE) HY-42618 864681-04-9 97.0% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Azido-PEG4-CH2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azido-PEG4-CH2-Boc is also a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-CH2-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. PEGs Alkyl/ether Cleavable Linker \| \| \| \| \| \| \| \| \| \| [1]. Shiladitya Sengupta, et al. Targeted drug delivery through affinity based linkers. WO2015148126A1. [2]. Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1 28(1):115228. [Content Brief]
Last Update	2025-04-01 14:45:47

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