V-9302 MedChemExpress (MCE)

Product Name	(S)-2-Amino-4-(bis(2-((3-methylbenzyl)oxy)benzyl)amino)butanoic acid hydrochloride
Synonyms	V-9302 HCl;(S)-2-Amino-4-(bis(2-((3-methylbenzyl)oxy)benzyl)amino)butanoic acid hydrochloride
CAS	2416138-42-4
EINECS
Chemical Formula	C34H39ClN2O4
Molecular Weight	575.15
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	V-9302 hydrochloride V-9302 hydrochloride MedChemExpress (MCE) HY-112683A 2416138-42-4 99.34% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions V-9302 hydrochloride V-9302 hydrochloride MedChemExpress (MCE) HY-112683A 2416138-42-4 99.34% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. V-9302 hydrochloride is a competitive antagonist of transmembrane glutamine flux. V-9302 hydrochloride selectively and potently targets the amino acid transporter ASCT2 (SLC1A5) not ASCT1. V-9302 hydrochloride inhibits ASCT2-mediated glutamine uptake (IC50=9.6 µM) in HEK-293 cells. V-9302 hydrochloride inhibits ASCT2-mediated glutamine uptake in human cells in a concentration-dependent fashion and exhibits a 100-fold improvement in potency over gamma-L-glutamyl-p-nitroanilide[1]. Pharmacological blockade of ASCT2 with V-9302 hydrochloride results in attenuated cancer cell growth and proliferation, increases cell death, and increases oxidative stress[1]. V-9302 hydrochloride (75 mg/kg i.p. daily fo 21 days) prevents tumor growth in both HCT-116 and HT29 xenograft models[1]. The combination of CB-839 and V-9302 (30 mg/kg i.p. SNU398 and MHCC97H cells were grown as tumor xenografts in BALB/c nude mice for 20 or 15 d, respectively) elicits a strong growth inhibition in both SNU398 and MHCC97H xenograft models, while single-drug treatment showed modest anti-tumor effects[2]. V-9302 (50 mg/kg i.p. daily for 5 days) displays markedly reduced tumor growth[3]. ASCT2 \| \| \| \| \| \| \| \| \| \| [1]. Schulte ML, et al. Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacyin preclinical models. Nat Med. 2018 Feb 24(2):194-202. [Content Brief] [2]. Jin H, et al. A powerful drug combination strategy targeting glutamine addiction for the treatment of human liver cancer. Elife. 2020 9:e56749. Published 2020 Oct 5. [Content Brief] [3]. Edwards DN, et al. Selective glutamine metabolism inhibition in tumor cells improves antitumor T lymphocyte activity in triple-negative breast cancer. J Clin Invest. 2021 131(4):e140100. [Content Brief]
Last Update	2025-04-01 14:45:47

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