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Supplier NameMedChemExpress (MCE)
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Product NameK-Ras ligand-Linker Conjugate 4
SynonymsK-Ras ligand-Linker Conjugate 4
CAS2378261-83-5
EINECS
Chemical FormulaC35H51N7O8
Molecular Weight697.82
inchi
Package10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg
PriceEmail to quote
DescriptionsK-Ras ligand-Linker Conjugate 4

K-Ras ligand-Linker Conjugate 4

MedChemExpress (MCE)

HY-130822

2378261-83-5

98.76%

-20°C, stored under nitrogen *In solvent : -80°C, 6 months

Descriptions

K-Ras ligand-Linker Conjugate 4

K-Ras ligand-Linker Conjugate 4

MedChemExpress (MCE)

HY-130822

2378261-83-5

98.76%

-20°C, stored under nitrogen *In solvent : -80°C, 6 months
-20°C, 1 month (stored under nitrogen)

Room temperature in continental US
may vary elsewhere.

K-Ras ligand-Linker Conjugate 4 incorporates a ligand for K-Ras recruiting moiety, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). K-Ras ligand-Linker Conjugate 4 can be used in the synthesis of PROTAC K-Ras Degrader-1 (HY-129523), which is potent PROTAC K-Ras degrader that exhibits ≥70% degradation efficacy in SW1573 cells.

PROTACs contain two different ligands connected by a linker
one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

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[1]. CREW, Andrew P., et al. MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE. WO2019195609A2.

Last Update2025-04-01 14:45:47
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