1-Naphthohydroxamic acid MedChemExpress (MCE)

Product Name	Naphthohydroxamicacid
Synonyms	NSC 57457 Naphthohydroxamicacid a-Naphthohydroxamic acid 1-Naphthohydroxamic acid alpha-naphthohydroxamicacid HDAC Inhibitor XIX, Compound 2 N-hydroxynaphthalene-1-carboxamide Synonyms NSC 57457 Naphthohydroxamicacid a-Naphthohydroxamic acid 1-Naphthohydroxamic acid alpha-naphthohydroxamicacid HDAC Inhibitor XIX, Compound 2 N-hydroxynaphthalene-1-carboxamide Naphthalene-1-carbohydroximic acid N-Hydroxy-1-naphthalenecarboxamide N-HYDROXYNAPHTHALENE-1-CARBOXAMIDE
CAS	6953-61-3
EINECS
Chemical Formula	C11H9NO2
Molecular Weight	187.19
inchi	InChI=1/C11H9NO2/c13-11(12-14)10-7-3-5-8-4-1-2-6-9(8)10/h1-7,14H,(H,12,13)
Package	1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	1-Naphthohydroxamic acid 1-Naphthohydroxamic acid MedChemExpress (MCE) HY-130538 6953-61-3 99.72% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions 1-Naphthohydroxamic acid 1-Naphthohydroxamic acid MedChemExpress (MCE) HY-130538 6953-61-3 99.72% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. 1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM. 1-Naphthohydroxamic acid is more selectively for HDAC8 than class I HDAC1 and class II HDAC6 (IC50 >100 μM). 1-Naphthohydroxamic acid does not increase global histone H4 acetylation and also does not reduce total intracellular HDAC activity.1-Naphthohydroxamic acid can induce tubulin acetylation. 1-Naphthohydroxamic acid (compound 2 20-40 μM 0-144 ?hours BE(2)-C, SK-N-BE(2) and SH-SY5Y cells) treatment reduces cell numbers in a concentration-dependent manner[2]. 1-Naphthohydroxamic acid (compound 2) at concentrations in the range of its in vitro IC50 against HDAC8 results in reduced cell density and outgrowth of neurite-like structures that stained positive for neurofilament.1-Naphthohydroxamic acid reduces the formation of clones in soft-agar concentration dependently[2]. When either cell type (HeLa and HEK293 cells) is treated with 1-Naphthohydroxamic acid (compound 2 0.8 μM, 4 μM, 20 μM or 100 μM), only tubulin becomes hyperacetylated[1]. Dose-limiting toxicities (DLTs) of 1-Naphthohydroxamic acid (compound 2 0-40 mg/kg intraperitoneal injection daily for 10 day NMRI Foxn1 nude mice) include weight loss and signs of liver toxicity, as evidenced by elevated plasma liver enzymes and detection of necrotic areas on histological liver examination. 1-Naphthohydroxamic acid has the maximum tolerable doses at 50?mg/kg per day. At these concentrations, neither body weight nor blood parameters are critically changed[3]. Pharmacokinetic studies after intraperitoneal administration of the inhibitors identified the half-life of 1-Naphthohydroxamic acid to be ~15?min, with a plasma peak concentration of ~30?μM[3]. HDAC8 14 μM (IC50) HDAC1 >100 μM (IC50) HDAC6 >100 μM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Krennhrubec K, et al. Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. Bioorg Med Chem Lett. 2007 May 15 17(10):2874-8. [Content Brief] [2]. Oehme I, et al. Histone deacetylase 8 in neuroblastoma tumorigenesis. Clin Cancer Res. 2009 Jan 1 15(1):91-9. [Content Brief]
Last Update	2025-04-01 14:45:47

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