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Supplier NameMedChemExpress (MCE)
Contactsales
Tel609-228-6898
Mobile609-228-6898
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Emailsales@medchemexpress.com; tech@medchemexpress.com
Websitehttps://www.medchemexpress.com/
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Product NameTCO-PEG3-acid
SynonymsTCO-PEG3-acid;TCO4-PEG3-COOH
CAS2141981-86-2
EINECS
Chemical FormulaC18H31NO7
Molecular Weight373.44
inchi
Package1 mg;5 mg;10 mg
PriceEmail to quote
DescriptionsTCO-PEG3-acid

TCO-PEG3-acid

MedChemExpress (MCE)

HY-140015

2141981-86-2

96.01%

Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Room temperature in continental US

Descriptions

TCO-PEG3-acid

TCO-PEG3-acid

MedChemExpress (MCE)

HY-140015

2141981-86-2

96.01%

Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Room temperature in continental US
may vary elsewhere.

TCO-PEG3-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. TCO-PEG3-acid is a click chemistry reagent, it contains a TCO group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing Tetrazine groups.

PROTACs contain two different ligands connected by a linker
one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

PEGs

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[1]. Wang Y, et al. Degradation of proteins by PROTACs and other strategies. Acta Pharm Sin B. 2020 Feb
10(2):207-238. [Content Brief]

Last Update2025-04-01 14:45:47
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