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Supplier NameMedChemExpress (MCE)
Contactsales
Tel609-228-6898
Mobile609-228-6898
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Emailsales@medchemexpress.com; tech@medchemexpress.com
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Product NameDBCO-PEG5-DBCO
SynonymsDBCO-PEG5-DBCO
CAS2363130-04-3
EINECS
Chemical FormulaC50H54N4O9
Molecular Weight854.99
inchi
Package5 mg;10 mg
PriceEmail to quote
DescriptionsDBCO-PEG5-DBCO

DBCO-PEG5-DBCO

MedChemExpress (MCE)

HY-140302

2363130-04-3

98.00%

Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month

Room temperature in continental US

Descriptions

DBCO-PEG5-DBCO

DBCO-PEG5-DBCO

MedChemExpress (MCE)

HY-140302

2363130-04-3

98.00%

Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month

Room temperature in continental US
may vary elsewhere.

DBCO-PEG5-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG5-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

PROTACs contain two different ligands connected by a linker
one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

PEGs

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[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct
36:553-562 [Content Brief]

Last Update2025-04-01 14:45:47
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