Cystamine MedChemExpress (MCE)

Product Name	2,2'-dithiobis(ethylamine)
Synonyms	L-1591;Cystinamine;Decarboxycystine;Mercamine disulfide;2,2'-Dithiobisethanamine;2,2'-dithiobis(ethylamine);2,2-DIAMINODIETHYLDISULPHIDE;2,2'-disulfanediyldiethanamine
CAS	51-85-4
EINECS	200-129-4
Chemical Formula	C4H12N2S2
Molecular Weight	152.28
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Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg;250 mg;500 mg
Price	Email to quote
Descriptions	Cystamine Cystamine MedChemExpress (MCE) HY-124476 51-85-4 99.79% Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Cystamine Cystamine MedChemExpress (MCE) HY-124476 51-85-4 99.79% Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Cystamine is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) . Cystamine has inhibition activity for caspase-3 with an IC50 value of 23.6 μM[1]. Cystamine (0-500 μM 0-16 h) inhibits recombinant active caspase-3 in a concentration-dependent manner[1]. Cystamine (250 μM 10 h) robustly increases the levels of glutathione[1]. Cystamine (oral, i.p. 112, 225 mg/kg) reduces Tgase activity and GGEL levels, lessens the behavioral and neuropathological severity, and extends survival in R6/2 transgenic HD mice[2]. Caspase 3 23.6 μM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Mathieu Lesort, et al. Cystamine inhibits caspase activity. Implications for the treatment of polyglutamine disorders. J Biol Chem. 2003 Feb 7 278(6):3825-30. [Content Brief] [2]. Alpaslan Dedeoglu, et al. Therapeutic effects of cystamine in a murine model of Huntington's disease. J Neurosci. 2002 Oct 15 22(20):8942-50. [Content Brief] [3]. Thomas M Jeitner, et al. Cystamine and cysteamine as inhibitors of transglutaminase activity in vivo. Biosci Rep. 2018 Sep 5 38(5):BSR20180691. [Content Brief]
Last Update	2025-04-01 14:45:47

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