DBCO-PEG4-NHS ester MedChemExpress (MCE)

Product Name	NHS-PEG4-DBCO
Synonyms	DBCO-PEG4-SE NHS-PEG4-DBCO DBCO-PEG4-SPA DBCO-PEG4-NHS ester DBCO-CONH-PEG4-NHS ester DBCO-PEG4-succinimidyl ester Dibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester Synonyms DBCO-PEG4-SE NHS-PEG4-DBCO DBCO-PEG4-SPA DBCO-PEG4-NHS ester DBCO-CONH-PEG4-NHS ester DBCO-PEG4-succinimidyl ester Dibenzocyclooctyne-PEG4-N-hydroxysuccinimidyl ester 2,5-Dioxo-1-pyrrolidinyl 20-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-17,20-dioxo-4,7,10,13-tetraoxa-16-azaeicosanoate 4,7,10,13-Tetraoxa-16-azaeicosanoic acid, 20-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-17,20-dioxo-, 2,5-dioxo-1-pyrrolidinyl ester
CAS	1427004-19-0
EINECS
Chemical Formula	C34H39N3O10
Molecular Weight	649.69
inchi
Package	1 mg;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	DBCO-PEG4-NHS ester DBCO-PEG4-NHS ester MedChemExpress (MCE) HY-140272 1427004-19-0 98.40% Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions DBCO-PEG4-NHS ester DBCO-PEG4-NHS ester MedChemExpress (MCE) HY-140272 1427004-19-0 98.40% Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. DBCO-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-PEG4-NHS ester is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. PROTACs contain two different ligands connected by a linker one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. PEGs \| \| \| \| \| \| \| \| \| \| [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct 36:553-562 [Content Brief]
Last Update	2025-04-01 14:45:47

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