Bupivacaine MedChemExpress (MCE)

Product Name	bupivacaine hydrochloride
Synonyms	Marcaina Bupivacaine Hcl Bupivocoine HCl bupivacaine hydrochloride BUPIVACAINE HYDROCHLORIDE Bupivacaine Hydrochloride, USP BUPIVACAINE HYDROCHLORIDE ANHYDROUS Synonyms Marcaina Bupivacaine Hcl Bupivocoine HCl bupivacaine hydrochloride BUPIVACAINE HYDROCHLORIDE Bupivacaine Hydrochloride, USP BUPIVACAINE HYDROCHLORIDE ANHYDROUS 1-butyl-2',6'-pipecoloxylididehydrochloride(+-) 2',6'-Pipecoloxylidide, 1-butyl-, hydrochloride (6CI) 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide (+,-)-1-butyl-2',6'-pipecoloxylididemonohydrochloride,monohydrate 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide hydrochloride 1-butyl-N-(2,6-dimethylphenyl)piperidine-2-carboxamide hydrochloride 2-Piperidinecarboxamide, 1-butyl-N-(2,6-dimethylphenyl)-, monohydrochloride Bupivacaine hydrochloride 1-Butyl-N-(2,6-dimethylphenyl)-2-piperidinecarboxamide hydrochloride
CAS	14252-80-3;18010-40-7
EINECS	627-065-3
Chemical Formula	C18H28N2O.ClH
Molecular Weight	324.89
inchi	InChI=1S/C18H28N2O.ClH/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3;/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21);1H
Package	10 mM * 1 mL;100 mg;500 mg
Price	Email to quote
Descriptions	Bupivacaine hydrochloride Bupivacaine hydrochloride MedChemExpress (MCE) HY-B0405A 18010-40-7 99.89% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 2 years Descriptions Bupivacaine hydrochloride Bupivacaine hydrochloride MedChemExpress (MCE) HY-B0405A 18010-40-7 99.89% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 2 years -20°C, 1 year (sealed storage, away from moisture and light) Room temperature in continental US may vary elsewhere. Bupivacaine hydrochloride is a NMDA receptor inhibitor.Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine hydrochloride can be used for the research of chronic pain. Bupivacaine hydrochloride inhibits NMDA receptor-mediated synaptic transmission in the dorsal horn of the spinal cord, an area critically involved in central sensitization[1]. Bupivacaine hydrochloride influences the voltage dependency of channel activation and steady-state inactivation by shifting the membrane potential of half-maximal activation/inactivation toward somewhat more negative membrane potentials. In their inactivated state, SCN5A channels are slightly sensitive toward Bupivacaine hydrochloride IC50=2.18±0.16 μM[2]. Bupivacaine hydrochloride reversibly inhibits the SK2 channel in a dose-dependent manner with the IC 50 of 16.5 μM[3]. NMDA Receptor \| \| \| \| \| \| \| \| \| \| [1]. Casati A, et, al. Bupivacaine, levobupivacaine and ropivacaine: are they clinically different? Best Pract Res Clin Anaesthesiol. 2005 Jun 19(2):247-68. [Content Brief] [2]. Dan J, et, al. Inhibition of gastric cancer by local anesthetic bupivacaine through multiple mechanisms independent of sodium channel blockade. Biomed Pharmacother. 2018 Jul 103:823-828. [Content Brief]
Last Update	2025-04-01 14:45:47

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