APN-C3-PEG4-azide MedChemExpress (MCE)

Product Name	APN-C3-PEG4-azide
Synonyms	APN-C3-PEG4-azide
CAS	2183440-32-4
EINECS
Chemical Formula	C24H32N6O6
Molecular Weight	500.56
inchi
Package	1 mg;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	APN-C3-PEG4-azide APN-C3-PEG4-azide MedChemExpress (MCE) HY-140841 2183440-32-4 98.56% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions APN-C3-PEG4-azide APN-C3-PEG4-azide MedChemExpress (MCE) HY-140841 2183440-32-4 98.56% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. APN-C3-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. APN-C3-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs contain two different ligands connected by a linker one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. PEGs \| \| \| \| \| \| \| \| \| \| [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct 36:553-562 [Content Brief]
Last Update	2025-04-01 14:45:47

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