Azido-PEG24-NHS ester MedChemExpress (MCE)

Product Name	Azido-PEG24-NHS ester
Synonyms	Azido-PEG24-NHS ester
CAS	2375600-46-5
EINECS
Chemical Formula	C55H104N4O28
Molecular Weight	1269.44
inchi
Package	10 mg;25 mg
Price	Email to quote
Descriptions	Azido-PEG24-NHS ester Azido-PEG24-NHS ester MedChemExpress (MCE) HY-140762 2375600-46-5 95.0% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Azido-PEG24-NHS ester Azido-PEG24-NHS ester MedChemExpress (MCE) HY-140762 2375600-46-5 95.0% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Azido-PEG24-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG24-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs contain two different ligands connected by a linker one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. PEGs Alkyl/ether \| \| \| \| \| \| \| \| \| \| [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct 36:553-562 [Content Brief]
Last Update	2025-04-01 14:45:47

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