N-(Azido-PEG2)-N-Boc-PEG4-NHS ester MedChemExpress (MCE)

Product Name	N-(Azido-PEG2)-N-Boc-PEG4-NHS ester
Synonyms	JUN 53956;N-(Azido-PEG2)-N-Boc-PEG4-NHS ester;(2,5-dioxopyrrolidin-1-yl) 3-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethyl-[(2-methylpropan-2-yl)oxycarbonyl]amino]ethoxy]ethoxy]ethoxy]ethoxy]propanoate
CAS	2093153-95-6
EINECS
Chemical Formula	C26H45N5O12
Molecular Weight	619.6618
inchi
Package	100 mg;250 mg;500 mg
Price	Email to quote
Descriptions	N-(Azido-PEG2)-N-Boc-PEG4-NHS ester N-(Azido-PEG2)-N-Boc-PEG4-NHS ester MedChemExpress (MCE) HY-140560 2093153-95-6 Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions N-(Azido-PEG2)-N-Boc-PEG4-NHS ester N-(Azido-PEG2)-N-Boc-PEG4-NHS ester MedChemExpress (MCE) HY-140560 2093153-95-6 Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. N-(Azido-PEG2)-N-Boc-PEG4-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Azido-PEG2)-N-Boc-PEG4-NHS ester is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. PROTACs contain two different ligands connected by a linker one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. PEGs Alkyl/ether \| \| \| \| \| \| \| \| \| \| [1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct 36:553-562 [Content Brief]
Last Update	2025-04-01 14:45:47

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