TTP-8307 MedChemExpress (MCE)

Product Name	TTP-8307
Synonyms	TTP-8307;Benzamide, N-[(1R)-1-(4-fluorophenyl)ethyl]-3-[2-(3-isoquinolinyl)-1H-imidazol-5-yl]-
CAS	950225-08-8
EINECS
Chemical Formula	C27H21FN4O
Molecular Weight	436.48
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	TTP-8307 TTP-8307 MedChemExpress (MCE) HY-124806 950225-08-8 99.63% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions TTP-8307 TTP-8307 MedChemExpress (MCE) HY-124806 950225-08-8 99.63% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. TTP-8307 is a potent inhibitor of the replication of several rhino- and enteroviruses. TTP-8307 inhibits coxsackievirus B3 (CVB3 EC50=1.2 μM) and poliovirus by interfering with the synthesis of viral RNA. TTP-8307 exerts antiviral activity through oxysterol-binding protein (OSBP). TTP-8307 targets the nonstructural protein 3A, inhibits the replication of coxsackievirus B3 (CVB3 Nancy) with EC50 of 1.2 μM. TTP-8307 inhibits the replication of coxsackievirus B3 and the three poliovirus Sabin strains, as well as coxsackieviruses A16 and A21 (EC50 of 0.85 and 5.34 μM). TTP-8307 inhibits human rhinoviruses (HRVs) 2, 29, 39, 45, 63, and 85. Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307[1]. TTP-8307 inhibits OSBP-dependent viruses encephalomyocarditis virus (EMCV) and HCV[2]. \| \| \| \| \| \| \| \| \| \| [1]. De Palma AM, et al. Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307. Antimicrob Agents Chemother. 2009 May 53(5):1850-7. [Content Brief] [2]. Albulescu L, et al. Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307. Antiviral Res. 2017 Apr 140:37-44. [Content Brief]
Last Update	2025-04-01 14:45:47

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