LY315920 sodium MedChemExpress (MCE)

Product Name	Varespladib sodium
Synonyms	LY 315920Na LY315920 sodium LY 315920 sodium Varespladib sodium LY315920 sodiuM salt NATRIUM[(1-BENZYL-2-ETHYL-3-OXAMOYLINDOOL-4-YL)OXY]ACETAAT [[3-(Aminooxoacetyl)-2-ethyl-1-(phenylmethyl)-1H-indol-4-yl]oxy]acetic acid monosodium salt
CAS	172733-42-5
EINECS
Chemical Formula	C21H19N2NaO5
Molecular Weight	402.37573
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	Varespladib sodium Varespladib sodium MedChemExpress (MCE) HY-13402A 172733-42-5 LY315920 sodium 98.0% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Varespladib sodium Varespladib sodium MedChemExpress (MCE) HY-13402A 172733-42-5 LY315920 sodium 98.0% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Varespladib sodium (LY315920 sodium) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib sodium exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively. Varespladib sodium (10 μM 24 and 48 hours HCjE cells) treatment results in complete inhibition of the RA-induced increase in MUC16 protein detected in cell lysates at both time points[2]. Varespladib sodium (10 μM 24 and 48 hours HCjE cells) treatment significantly inhibits RA-induced MUC16 expression by 100% at 24 hours and 99% at 48 hours[2]. Varespladib sodium treatment inhibits human sPLA2-induced release of thromboxane A2 (TXA2) from isolated guinea pig lung bronchoalveolar lavage cells with an IC50 of 0.79 μM. And the ED50 for Varespladib sodium is 16.1 mg/kg[1]. sPLA2 9 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Snyder DW, et al. Pharmacology of LY315920/S-5920, [[3-(aminooxoacetyl)-2-ethyl-1- (phenylmethyl)-1H-indol-4-yl]oxy] acetate, a potent and selective secretory phospholipase A2 inhibitor: A new class of anti-inflammatory drugs, SPI. J Pharmacol Exp Ther. 1 [Content Brief] [2]. Hori Y, et al. Effect of retinoic acid on gene expression in human conjunctival epithelium: secretory phospholipase A2 mediates retinoic acid induction of MUC16. Invest Ophthalmol Vis Sci. 2005 Nov 46(11):4050-61. [Content Brief]
Last Update	2025-04-01 14:45:47

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