PKCβ inhibitor 1 MedChemExpress (MCE)

Product Name	PKCβ inhibitor 1
Synonyms	KUN79359;PKCβ Inhibitor;PKCβ inhibitor 1;3-anilino-4-[1-(3-imidazol-1-ylpropyl)indol-3-yl]pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-[1-[3-(1H-imidazol-1-yl)propyl]-1H-indol-3-yl]-4-(phenylamino)-
CAS	257879-35-9
EINECS
Chemical Formula	C24H21N5O2
Molecular Weight	411.46
inchi
Package	10 mM * 1 mL;500 μg;1 mg;5 mg
Price	Email to quote
Descriptions	PKCβ inhibitor 1 PKCβ inhibitor 1 MedChemExpress (MCE) HY-13335 257879-35-9 99.40% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions PKCβ inhibitor 1 PKCβ inhibitor 1 MedChemExpress (MCE) HY-13335 257879-35-9 99.40% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. PKCβ inhibitor 1 is a potent, ATP-competitive, and selective PKCβ inhibitor with IC50s of 21 and 5 nM for human PKCβ1 and PKCβ2, respectively. PKCβ inhibitor 1 exhibits selectivity of more than 60-fold in favor of PKCβ2 relative to other PKC isozymes (PKCα, PKCγ, and PKCε). PKCβ inhibitor 1 (0-30 μM 48 hours) suppresses tumor cell proliferation in a time- and dose-dependent manner[2]. PKCβ inhibitor 1 (14 μM 2-48 hours) induces apoptosis in 2F7 cells[2]. PKCβ inhibitor 1 (15 μM 2-48 hours) inhibits cell cycle progression in 2F7 and BCBL-1 cells[2]. PKCβ (15 or 14 μM, respectively 2-48 hours) inhibitor 1 reduces the expression of phospho-PKCβ in BCBL-1 and 2F7 cells[2]. PKCβ inhibitor 1(0-48 hours) suppresses GSK3β, mTOR, and S6 phosphorylation[2]. human PKCβ1 21 nM (IC50) human PKCβ2 5 nM (IC50) PKCα 331 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Tanaka M, et al. Synthesis of anilino-monoindolylmaleimides as potent and selective PKCbeta inhibitors. Bioorg Med Chem Lett. 2004 Oct 18 14(20):5171-4. [Content Brief] [2]. Saba NS, et al. Protein kinase C-beta inhibition induces apoptosis and inhibits cell cycle progression in acquired immunodeficiency syndrome-related non-hodgkin lymphoma cells. J Investig Med. 2012 Jan 60(1):29-38. [Content Brief]
Last Update	2025-04-01 14:45:47

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