Chloroquine MedChemExpress (MCE)

Product Name	CHLOROQUINE
Synonyms	Chlorquin Chlorochin CHLOROQUINE Chloraquine Chloroquina Chlorochine Chloroquinium Synonyms Chlorquin Chlorochin CHLOROQUINE Chloraquine Chloroquina Chlorochine Chloroquinium (7-chloro-4-(4-diethylamino-1-methylbutylamino)-quinoline 1,4-Pentanediamine, N4-(7-chloro-4-quinolinyl)-N1,N1-diethyl-
CAS	54-05-7
EINECS	200-191-2
Chemical Formula	C18H26ClN3
Molecular Weight	319.87
inchi
Package	10 mM * 1 mL;50 mg;100 mg;200 mg;500 mg
Price	Email to quote
Descriptions	Chloroquine Chloroquine MedChemExpress (MCE) HY-17589A 54-05-7 99.50% 4°C, protect from light In solvent : -80°C, 6 months Descriptions Chloroquine Chloroquine MedChemExpress (MCE) HY-17589A 54-05-7 99.50% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. Chloroquine is an antimalarial and anti-inflammatory agent widely used to treat malaria and rheumatoid arthritis. Chloroquine is an autophagy and toll-like receptors (TLRs) inhibitor. Chloroquine is highly effective in the control of SARS-CoV-2 (COVID-19) infection in vitro (EC50=1.13 μM). Chloroquine (CHQ, 20 μM) inhibits IL-12p70 release and reduces Th1-priming capacity of activated human monocyte-derived Langerhans-like cells (MoLC). Chloroquine (20 μM) enhances IL-1–induced IL-23 secretion in MoLC and subsequently increases IL-17A release by primed CD4+ T cells[1]. Chloroquine (25 μM) suppresses MMP-9 mRNA expression in normoxia and hypoxia in parental MDA-MB-231 cells. Chloroquine has cell-, dose- and hypoxia-dependent effects on MMP-2, MMP-9 and MMP-13 mRNA expression[2]. TLR7 and TLR9 inhibition using IRS-954 or chloroquine significantly reduces HuH7 cell proliferation in vitro[3]. Chloroquine (0.01-100 μM 48 hours) potently blocked virus infection (vero E6 cells infected with SARS-CoV-2) at low-micromolar concentration (EC50=1.13 μM). Chloroquine blocks virus infection by increasing endosomal pH required for virus/cell fusion, as well as interfering with the glycosylation of cellular receptors of SARS-CoV[4]. Chloroquine (80 mg/kg, i.p.) does not prevent the growth of the triple-negative MDA-MB-231 cells with high or low TLR9 expression levels in the orthotopic mouse model[2]. TLR7 and TLR9 inhibition using IRS-954 or chloroquine significantly inhibits tumour growth in the mouse xenograft model. HCC development in the DEN/NMOR rat model is also significantly inhibited by Chloroquine[3]. Plasmodium Malaria TLRs SARS-COV-2 HIV-1 \| \| \| \| \| \| \| \| \| \| [1]. Said A, et al. Chloroquine promotes IL-17 production by CD4+ T cells via p38-dependent IL-23 release by monocyte-derived Langerhans-like cells. J Immunol. 2014 Dec 15 193(12):6135-43. [Content Brief] [2]. Tuomela J, et al. Chloroquine has tumor-inhibitory and tumor-promoting effects in triple-negative breast cancer. Oncol Lett. 2013 Dec 6(6):1665-1672. [Content Brief] [3]. Mohamed FE, et al. Effect of toll-like receptor 7 and 9 targeted therapy to prevent the development of hepatocellular carcinoma. Liver Int. 2014 Jul 2. doi: 10.1111/liv.12626. [Content Brief] [4]. Colson P, et al. Chloroquine and hydroxychloroquine as available weapons to fight COVID-19. Int J Antimicrob Agents. 2020 55(4):105932. [Content Brief] [5]. Savarino A, et al. The anti-HIV-1 activity of chloroquine. J Clin Virol. 2001 20(3):131-135. [Content Brief]
Last Update	2025-04-01 14:45:47

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