Ethyl pyruvate MedChemExpress (MCE)

Product Name	Ethyl pyruvate
Synonyms	PAEE PYR ET ETHYL PYRUVATE Ethyl pyruvate RARECHEM AL BI 0116 ETHYL 2-OXOPROPANOATE ethyl 2-oxopropanoate Synonyms PAEE PYR ET ETHYL PYRUVATE Ethyl pyruvate RARECHEM AL BI 0116 ETHYL 2-OXOPROPANOATE ethyl 2-oxopropanoate Ethyl 2-oxopropionate ETHYL 2-OXOPROPIONATE ETHYL 2-OXOPROPRIONATE PYRUVIC ACID ETHYL ESTER Pyruvic acid ethyl ester Brenztraubensaeure-ethylester Ethyl pyruvate,(Pyruvic acid ethyl ester)
CAS	617-35-6
EINECS	210-511-2
Chemical Formula	C5H8O3
Molecular Weight	116.12
inchi	InChI=1/C5H8O3/c1-3-8-5(7)4(2)6/h3H2,1-2H3
Package	10 mM * 1 mL;100 mg
Price	Email to quote
Descriptions	Ethyl pyruvate Ethyl pyruvate MedChemExpress (MCE) HY-Y1362 617-35-6 99.00% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Ethyl pyruvate Ethyl pyruvate MedChemExpress (MCE) HY-Y1362 617-35-6 99.00% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Ethyl pyruvate is a simple derivative of the endogenous metabolite pyruvate. Ethyl pyruvate is an HMGB1 release inhibitor. Ethyl pyruvate can induce apoptosis by autophagy. Ethyl pyruvate has anti-inflammatory, antioxidant and anti-tumor activity. Ethyl pyruvate can be used in the study of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Ethyl pyruvate (10 mM, 1 h) has no toxic effect on N9 microglial cells in the range of 1-10 mM. The activation of microglia NLRP3 inflammasome is decreased by inhibiting the HMGB1/ NF-κB /miR-223 signaling pathway[2]. Ethyl pyruvate (10-40 mM, 6, 24 h) induces apoptosis in MC38 cells[3]. Ethyl pyruvate (5-15 mM, 2 h) has an IC50 value of 28.83 mM on mouse peritoneal macrophages. Endotoxemia and sepsis are prevented by inhibiting caspase-11-dependent pyroptosis [4]. Ethyl pyruvate (80 mg/kg intraperitoneal injection for 9 consecutive days) inhibits tumor growth in a mouse liver tumor model[3]. Ethyl pyruvate (2 or 40 mg/kg, intraperitoneal injection) has reduced lipid peroxidation and anti-inflammatory effects in a rat model of paraquat intoxication[5]. \| \| \| \| \| \| \| \| \| \| [1]. Fink MP. Ethyl pyruvate: a novel anti-inflammatory agent. J Intern Med. 2007 Apr 261(4):349-62. [Content Brief] [2]. Olcum M, Tufekci KU, Durur DY, et al. Ethyl Pyruvate Attenuates Microglial NLRP3 Inflammasome Activation via Inhibition of HMGB1/NF-κB/miR-223 Signaling. Antioxidants (Basel). 2021 10(5):745. [Content Brief] [3]. Liang X, et al. Ethyl pyruvate administration inhibits hepatic tumor growth. J Leukoc Biol. 2009 Sep 86(3):599-607. [Content Brief] [4]. Qiu X, et al. Ethyl pyruvate confers protection against endotoxemia and sepsis by inhibiting caspase-11-dependent cell pyroptosis. Int Immunopharmacol. 2020 Jan 78:106016. [Content Brief] [5]. Lee J, et al. Protective effects of ethyl pyruvate treatment on paraquat-intoxicated rats. Hum Exp Toxicol. 2008 Jan 27(1):49-54.
Last Update	2025-04-01 14:45:47

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