Teijin compound 1 hydrochloride MedChemExpress (MCE)

Product Name	Teijin compound 1
Synonyms	Teijin compound 1
CAS	1313730-14-1
EINECS
Chemical Formula	C21H22Cl2F3N3O2
Molecular Weight	439.8636
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	CCR2 antagonist 4 hydrochloride CCR2 antagonist 4 hydrochloride MedChemExpress (MCE) HY-103362 1313730-14-1 Teijin compound 1 hydrochloride 99.86% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions CCR2 antagonist 4 hydrochloride CCR2 antagonist 4 hydrochloride MedChemExpress (MCE) HY-103362 1313730-14-1 Teijin compound 1 hydrochloride 99.86% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. CCR2 antagonist 4 hydrochloride (Teijin compound 1 hydrochloride) is a potent and specific CCR2 antagonist, with IC50s of 180 nM for CCR2b. CCR2 antagonist 4 hydrochloride potently inhibits MCP-1-induced chemotaxis with an IC50 of 24 nM. Ile263 and Thr292 in CCR2 contribute significantly to binding of CCR2 antagonist 4 in CCR2. Residue Glu291 in TM7, a highly conserved residue in many CC chemokine receptors, contributes substantially to binding of the protonated CCR2 antagonist 4 hydrochloride, and CCL2. His121 on TM3 and Ile263 on TM6 also strongly interact with CCR2 antagonist 4 hydrochloride[2]. In ApoE-deficient mice, Vp-TSL targets specifically aortic plaque endothelial VCAM-1 and CCR2 antagonist 4 hydrochloride reduces the mouse monocyte/macrophage cell line (RAW 264.7) adhesion/ infiltration into the aorta[3]. CCR2b 180 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Moree WJ, et al. Potent antagonists of the CCR2b receptor. Part 3: SAR of the (R)-3-aminopyrrolidine series. Bioorg Med Chem Lett. 2008 Mar 15 18(6):1869-73. [Content Brief] [2]. Hall SE, et al. Elucidation of binding sites of dual antagonists in the human chemokine receptors CCR2 and CCR5. Mol Pharmacol. 2009 Jun 75(6):1325-36. [Content Brief] [3]. Calin M, et al. VCAM-1 directed target-sensitive liposomes carrying CCR2 antagonists bind to activated endothelium and reduce adhesion and transmigration of monocytes. Eur J Pharm Biopharm. 2015 Jan 89:18-29. [Content Brief]
Last Update	2025-04-01 14:45:47

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