Acesulfame MedChemExpress (MCE)

Product Name	Acesulfame Potassium
Synonyms	Sunette Sweet One Acesulfame-K Acesulfame k acesulfame k fcciv Acesulfamum Kalicum Acesulfame Potassium Synonyms Sunette Sweet One Acesulfame-K Acesulfame k acesulfame k fcciv Acesulfamum Kalicum Acesulfame Potassium potassium 6-methyl-1,2,3-oxathiazin-4-olate 2,2-dioxide 6-methyl-1,2,3-oxathiazin-4(3h)-one 2,2-dioxide potassium salt 6-Methyl-1,2,3-Oxathiazin-4(3H)-One-2,2-Dioxide,Potassium Salt potassium salt of 6methyl-1,2,3-oxathiazine-4(3H)-one-2,2-dioxide Potassium Salt of 6-methyl-1,2,3-oxathiazin-4(3H)-one-2,2-dioxide
CAS	55589-62-3
EINECS	259-715-3
Chemical Formula	C4H4KNO4S
Molecular Weight	201.24
inchi	InChI=1/C4H5NO4S.K/c1-3-2-4(6)5-10(7,8)9-3;/h2H,1H3,(H,5,6);/q;+1/p-1
Package	500 mg
Price	Email to quote
Descriptions	Acesulfame potassium Acesulfame potassium MedChemExpress (MCE) HY-D0195 55589-62-3 99.38% -20°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Acesulfame potassium Acesulfame potassium MedChemExpress (MCE) HY-D0195 55589-62-3 99.38% -20°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Acesulfame potassium is a synthetic sweetener. Long-term use of Acesulfame potassium can affect cognitive function, possibly by altering the neurometabolic functions in mice. Acesulfame potassium can suppress autophagic degradation of PD-L1 in RIL-175 and SK-Hep1 cells through the ERK1/2-mTORC1-ULK1 pathway, which may be related to immune evasion in cancer cells. Acesulfame potassium can be used in research on neurological diseases, metabolic disorders, cancer, and immune evasion. Acesulfame potassium (1 mM, 24 hours) upregulates PD-L1 protein levels in RIL-175 and SK-Hep1 cells[2]. Acesulfame potassium (1 mM, 24 hours) increases granzyme B production in RIL-175 and SK-Hep1 cells co-cultured with T cells[2]. Acesulfame potassium (1 mM, 24 hours) activates ERK1/2-mTORC1-ULK1 pathway to suppress autophagic degradation of PD-L1 in RIL-175 and SK-Hep1 cells[2]. Acesulfame potassium (5-25 mM, 24 hours) inhibites mitochondrial metabolism in SH-SY5Y cells[4]. Acesulfame potassium (5-25 mM, 24 hours) inhibites ATP production in cells and reduced phosphorylation of neuroprotective proteins, impaires energy metabolism and neuroprotective functions in SH-SY5Y cells[4]. Acesulfame potassium (37.5 mg/kg, p.o., once daily for 4 weeks) increases body weight in male CD-1 mice and altered their gut microbiome composition[3]. Long-term intake of Acesulfame potassium (12.5 mM, administered via drinking water for 40 weeks) affects the neurometabolic functions in C57BL/6J mice[4]. \| \| \| \| \| \| \| \| \| \| [1]. Cong WN, et al. Long-term artificial sweetener acesulfame potassium treatment alters neurometabolic functions in C57BL/6J mice. PLoS One. 2013 Aug 7 8(8):e70257. [Content Brief] [2]. Kim DH, et al. Acesulfame potassium upregulates PD-L1 in HCC cells by attenuating autophagic degradation. Biochem Biophys Res Commun. 2024 Jun 4 711:149921. [Content Brief] [3]. Bian X, et al. The artificial sweetener acesulfame potassium affects the gut microbiome and body weight gain in CD-1 mice. PLoS One. 2017 Jun 8 12(6):e0178426. [Content Brief] [4]. Cong WN, et al. Long-term artificial sweetener acesulfame potassium treatment alters neurometabolic functions in C57BL/6J mice. PLoS One. 2013 Aug 7 8(8):e70257. [Content Brief]
Last Update	2025-04-01 14:45:47

MedChemExpress (MCE) also provides

Thalidomide-4-O-C2-NH2

Category: Signaling Pathways
CAS: 2341840-99-9
Last Update: 2025-04-01 14:45:47

PPARα-MO-1

Category: Signaling Pathways
CAS: 810677-36-2
Last Update: 2025-04-01 14:45:47

Netupitant N-oxide

Category: Signaling Pathways
CAS: 910808-11-6
Last Update: 2025-04-01 14:45:47

MK-0812

Category: Signaling Pathways
CAS: 624733-88-6
Last Update: 2025-04-01 14:45:47

TS-011

Category: Signaling Pathways
CAS: 339071-18-0
Last Update: 2025-04-01 14:45:47

SCH 530348 sulfate

Category: Signaling Pathways
CAS: 705260-08-8
Last Update: 2025-04-01 14:45:47

BAG 956

Category: Signaling Pathways
CAS: 853910-02-8
Last Update: 2025-04-01 14:45:47

YM758

Category: Signaling Pathways
CAS: 312752-85-5
Last Update: 2025-04-01 14:45:47


Supplier Name	MedChemExpress (MCE)
Contact	sales
Tel	609-228-6898
Mobile	609-228-6898
QQ
Email	sales@medchemexpress.com; tech@medchemexpress.com
Website	https://www.medchemexpress.com/
Wechat

Request for quotation

Supplier Contact