Zinostatin; Vinostatin MedChemExpress (MCE)

Product Name	NEOCARZINOSTATIN
Synonyms	Aids002003;NSC-157365;a8544527g1;Aids-002003;neocarcinostatin;NEOCARZINOSTATIN;neocarzinostatink;neocarzinostatin from streptomyces carzinostaticus;NEOCARZINOSTATIN FROM STREPTOMYCEC CARZINOSTATICUS
CAS	9014-02-2
EINECS
Chemical Formula
Molecular Weight
inchi
Package	100 μg (0.62 mgmL * 161 μL in 20 mM MES buffer pH=5.5)
Price	Email to quote
Descriptions	Neocarzinostatin Neocarzinostatin MedChemExpress (MCE) HY-111183 9014-02-2 Zinostatin Descriptions Neocarzinostatin Neocarzinostatin MedChemExpress (MCE) HY-111183 9014-02-2 Zinostatin Vinostatin 99.0% Solution, -20°C, 2 years Room temperature in continental US may vary elsewhere. Neocarzinostatin, a potent DNA-damaging, anti-tumor antibiotic, recognizes double-stranded DNA bulge and induces DNA double strand breaks (DSBs). Neocarzinostatin induces apoptosis. Neocarzinostatin has potential for EpCAM-positive cancers treatment . The EpCAM aptamer conjugated Neocarzinostatin (NCS) shows specificity to EpCAM-positive cells. The effects of the conjugates on cancer cells are impressive as the conjugate arrests the cell cycle and promoted apoptosis and necrosis. The high levels of PARP expression confirmed the DNA breaks upon conjugate treatment. NCS conjugated with EpCAM can be targeted to cancer cells sparing normal cells[3]. The IC50 values of Neocarzinostatin (72 hours) to C6 cells and U87MG cells were 493.64 nM, 462.96 nM, respectively[4]. In human tumor cell lines of different tissue origins, sensitivity to neocarzinostatin is proportional to the product of the relative contents of Bcl-2 and caspase-3[5]. \| \| \| \| \| \| \| \| \| \| [1]. Athyala PK, et al. Probing the biophysical interaction between Neocarzinostatin toxin and EpCAM RNA aptamer. Biochem Biophys Res Commun. 2016 Jan 8 469(2):257-62. [Content Brief] [2]. Allen Taylor, et al. Ubiquitination capabilities in response to neocarzinostatin and H2O2 stress in cell lines from patients with ataxia-telangiectasia. Oncogene (2002) 21, 4363- 4373. [3]. Athyala PK, et al. Neocarzinostatin, Aptamer Conjugates for Targeting EpCAM-positive Tumor Cells. Anticancer Res. 2017 Jul 37(7):3615-3629. [Content Brief] [4]. Tianqin G, et al. Synergistic Anti-glioma Effects in Vitro and in Vivo of Enediyne Antibiotic Neocarzinostatin and Paclitaxel via Enhanced Growth Delay and Apoptosis-Induction. Biol Pharm Bull. 2016 Oct 1 39(10):1623-1630. [Content Brief] [5]. Rogers D, et al. Molecular predictors of human nervous system cancer responsiveness to enediyne chemotherapy. [Content Brief]
Last Update	2025-04-01 14:45:47

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