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Supplier NameMedChemExpress (MCE)
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Product NameThalidomide-NH-C6-NH2 TFA
SynonymsThalidomide-NH-C6-NH2 TFA;Pomalidomide Related Compound 11 Triflate;4-((6-Aminohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione 2,2,2-trifluoroacetate
CAS2093386-51-5
EINECS
Chemical FormulaC21H25F3N4O6
Molecular Weight486.45
inchi
Package10 mM * 1 mL;50 mg;100 mg
PriceEmail to quote
DescriptionsThalidomide-NH-C6-NH2 TFA

Thalidomide-NH-C6-NH2 TFA

MedChemExpress (MCE)

HY-129704A

2093386-51-5

99.82%

-20°C, stored under nitrogen *In solvent : -80°C, 6 months

Descriptions

Thalidomide-NH-C6-NH2 TFA

Thalidomide-NH-C6-NH2 TFA

MedChemExpress (MCE)

HY-129704A

2093386-51-5

99.82%

-20°C, stored under nitrogen *In solvent : -80°C, 6 months
-20°C, 1 month (stored under nitrogen)

Room temperature in continental US
may vary elsewhere.

Thalidomide-NH-C6-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

PROTACs contain two different ligands connected by a linker
one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Cereblon

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[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Sep 12
62(17):8152-8163. [Content Brief]

Last Update2025-04-01 14:45:47
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