SD-169 MedChemExpress (MCE)

Product Name	1H-indole-5-carboxamide
Synonyms	SD-169 5-CarbaMoylindole 1H-indole-5-carboxamide 5-(AMinocarbonyl)-1H-indole 1H-Indole-5-carboxamide(9CI) p38 MAP Kinase Inhibitor VII, SD-169 5-(Aminocarbonyl)-1H-indole, 5-Carbamoylindole, 5-Carboxamidoindole Synonyms SD-169 5-CarbaMoylindole 1H-indole-5-carboxamide 5-(AMinocarbonyl)-1H-indole 1H-Indole-5-carboxamide(9CI) p38 MAP Kinase Inhibitor VII, SD-169 5-(Aminocarbonyl)-1H-indole, 5-Carbamoylindole, 5-Carboxamidoindole 5-(Aminocarbonyl)-1H-indole, 5-Carbamoylindole, 5-Carboxamidoindole
CAS	1670-87-7
EINECS
Chemical Formula	C9H8N2O
Molecular Weight	160.17
inchi	InChI=1/C9H8N2O/c10-9(12)7-1-2-8-6(5-7)3-4-11-8/h1-5,11H,(H2,10,12)
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	SD-169 SD-169 MedChemExpress (MCE) HY-W015445 1670-87-7 99.91% 4°C, protect from light In solvent : -80°C, 6 months Descriptions SD-169 SD-169 MedChemExpress (MCE) HY-W015445 1670-87-7 99.91% 4°C, protect from light In solvent : -80°C, 6 months -20°C, 1 month (protect from light) Room temperature in continental US may vary elsewhere. SD-169 is an orally active ATP-competitive inhibitor of p38α MAPK, with an IC50 of 3.2 nM. SD-169 also weakly inhibits p38β MAPK with an IC50 of 122 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation. SD-169 significantly reduces p38 and HSP60 expression in T cells of the pancreatic beta islets[1]. SD-169 demonstrates 38-fold potency against p38α MAP kinase (IC50=3.2 nM) than p38β MAP kinase (IC50=122 nM)[1]. p38α MAPK 3.2 nM (IC50) p38β MAPK 122 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Medicherla S, et al. Preventive and therapeutic potential of p38 alpha-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes. J Pharmacol Exp Ther. 2006 Jul 318(1):99-107. [Content Brief]
Last Update	2025-04-01 14:45:47

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