BAL8557-002 MedChemExpress (MCE)

Product Name	Isavuconazonium sulfate
Synonyms	BAL 8557-002 Isavuconazon Edoxaban Free Base ISAVUCONAZOLE SULFAT savuconazonium Sulfate Isavuconazonium sulfate API-Antifungal Infection Synonyms BAL 8557-002 Isavuconazon Edoxaban Free Base ISAVUCONAZOLE SULFAT savuconazonium Sulfate Isavuconazonium sulfate API-Antifungal Infection N-Methylglycine [2-[[[1-[1-[(2R,3R)-3-[4-(4-cyanophenyl)-2-thiazolyl]-2-(2,5-difluorophenyl)-2-hydroxybutyl]-4H-1,2,4-triazolium-4-yl]ethoxy]carbonyl]methylamino]-3-pyridinyl]methyl ester sulfate
CAS	946075-13-4
EINECS
Chemical Formula	C35H35F2N8O5S.HSO4
Molecular Weight	814.8353464
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Isavuconazonium sulfate Isavuconazonium sulfate MedChemExpress (MCE) HY-100373 946075-13-4 BAL8557-002 98.53% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Isavuconazonium sulfate Isavuconazonium sulfate MedChemExpress (MCE) HY-100373 946075-13-4 BAL8557-002 98.53% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Isavuconazonium sulfate (BAL8557-002) is an orally active broad-spectrum antifungal molecule. Isavuconazonium sulfate is a precursor of the triazole antifungal active molecule Isavuconazole. Isavuconazonium sulfate can be used in the study of invasive aspergillosis, mucormycosis, blastomycosis, and Acanthamoeba keratitis. Isavuconazonium sulfate (0.006 nM-50 μM) inhibits trophoblast activity of three T4-genotype strains of Acanthamoeba (Ma, CDC:V240 and MEEI 0184) with EC50 vaules of 0.001 μM, 0.037 μM and 0.024 μM, respectively. And (100-200 μM 48 h) has vesicle-extinguishing activity in three tested strains Ma, CDC:V240, and MEEI 0184 with mean minimum vesicle extinguishing concentration (MCC) of 167.1 μM, 136.0 μM, and 187.5 μM, respectively[2]. Isavuconazonium sulfate inhibits bacteria with minimum inhibitory concentration (MIC) [5]. Isavuconazonium sulfate (215 mg/kg p.o. Three times a day for 4 days) has anti-R.delemar virus activity in ICR mice infected with mucormycosis[4]. \| \| \| \| \| \| \| \| \| \| [1]. Kovanda L L, et al. Isavuconazonium sulfate: a new agent for the treatment of invasive aspergillosis and invasive mucormycosis[J]. Expert review of clinical pharmacology, 2016, 9(7): 887-897. [2]. Shing B, et al. Evaluation of Amebicidal and Cysticidal Activities of Antifungal Drug Isavuconazonium Sulfate against Acanthamoeba T4 Strains. Pharmaceuticals (Basel). 2021 Dec 11 14(12):1294. [Content Brief] [3]. Slain D, et al. Isavuconazonium sulfate: a novel antifungal agent[J]. Current Fungal Infection Reports, 2015, 9: 302-313. [4]. Luo G, et al. Isavuconazole therapy protects immunosuppressed mice from mucormycosis[J]. Antimicrobial agents and chemotherapy, 2014, 58(4): 2450-2453. [5]. Scolarici MJ, et al. The Role of Isavuconazonium Sulphate for the Treatment of Blastomycosis: A Case Series and Antifungal Susceptibility. Open Forum Infect Dis. 2022 Apr 27 9(7):ofac220. [Content Brief]
Last Update	2025-04-01 14:45:47

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