Dehydrolithocholic acid; 3-oxoLCA MedChemExpress (MCE)

Product Name	DEHYDROLITHOCHOLIC ACID
Synonyms	3-KETOCHOLANIC ACID 3-ketolithocholicacid DEHYDROLITHOCHOLIC ACID (5-beta)-cholan-24-oicaci 5BETA-CHOLANIC ACID-3-ONE 3-KETO-5BETA-CHOLANIC ACID 3-oxo-5-beta-cholan-24-oicaci Synonyms 3-KETOCHOLANIC ACID 3-ketolithocholicacid DEHYDROLITHOCHOLIC ACID (5-beta)-cholan-24-oicaci 5BETA-CHOLANIC ACID-3-ONE 3-KETO-5BETA-CHOLANIC ACID 3-oxo-5-beta-cholan-24-oicaci 3-oxo-5-beta-cholan-24-oicacid
CAS	1553-56-6
EINECS
Chemical Formula	C24H38O3
Molecular Weight	374.56
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	3-Oxo-5β-cholanoic acid 3-Oxo-5β-cholanoic acid MedChemExpress (MCE) HY-125801 1553-56-6 Dehydrolithocholic acid Descriptions 3-Oxo-5β-cholanoic acid 3-Oxo-5β-cholanoic acid MedChemExpress (MCE) HY-125801 1553-56-6 Dehydrolithocholic acid 3-oxoLCA 99.29% -20°C, stored under nitrogen In solvent : -80°C, 6 months -20°C, 1 month (stored under nitrogen) Room temperature in continental US may vary elsewhere. 3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid), a bile acid metabolite, inhibits the diferentiation of TH17 cells by directly binding to the key transcription factor RORγt (Kd=1.13 μM). Treatment with 3-Oxo-5β-cholanoic acid significantly reduced the activity of the RORγt reporter. These data suggest that 3-Oxo-5β-cholanoic acid probably inhibits TH17 cell differentiation by physically interacting with RORγt, and inhibiting its transcriptional activity[1]. 3-Oxo-5β-cholanoic acid (Dehydrolithocholic acid) (0.3% (w/w) p.o. for 1 week) significantly reduces the percentage of ileal TH17 cells[1]. \| \| \| \| \| \| \| \| \| \| [1]. Hang S, et al. Bile acid metabolites control TH17 and Treg cell differentiation. Nature. 2019 Dec 576(7785):143-148. [Content Brief]*
Last Update	2025-04-01 14:45:47

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