ChemBK
  • Home
  • Product Category
  • CHN
  1. Home
  2. CAS 1370261-96-3
  3. Supplier List
  4. MedChemExpress (MCE)
  5. Signaling Pathways
  6. P505-15; PRT-2607; BIIB-057

Request for quotation








Supplier Contact

Supplier NameMedChemExpress (MCE)
Contactsales
Tel609-228-6898
Mobile609-228-6898
QQ
Emailsales@medchemexpress.com; tech@medchemexpress.com
Websitehttps://www.medchemexpress.com/
Wechat
Product NamePRT062607
SynonymsPRT062607
CAS1370261-96-3
EINECS
Chemical FormulaC19H23N9O
Molecular Weight393.4456
inchi
Package1 mg;5 mg;10 mg;25 mg;50 mg
PriceEmail to quote
DescriptionsPRT062607

PRT062607

MedChemExpress (MCE)

HY-15322

1370261-96-3

P505-15

Descriptions

PRT062607

PRT062607

MedChemExpress (MCE)

HY-15322

1370261-96-3

P505-15
PRT-2607
BIIB-057

97.13%

Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month

Room temperature in continental US
may vary elsewhere.

PRT062607(P505-15
PRT-2607
BIIB-057) is a highly specific and potent inhibitor of Syk with IC50 of 1-2 nM
>80-fold selective for Syk than Fgr, Lyn, FAK, Pyk2 and Zap70.

| | | |

| | | | | |



[1]. Coffey G, et al. Specific inhibition of spleen tyrosine kinase suppresses leukocyte immune function and inflammation in animal models of rheumatoid arthritis. J Pharmacol Exp Ther. 2012 Feb
340(2):350-9. [Content Brief]

[2]. Spurgeon SE, et al. The selective SYK inhibitor P505-15 (PRT062607) inhibits B cell signaling and function in vitro and in vivo and augments the activity of fludarabine in chronic lymphocytic leukemia. J Pharmacol Exp Ther. 2013 Feb
344(2):378-87. [Content Brief]

[3]. Hoellenriegel J, et al. Selective, novel spleen tyrosine kinase (Syk) inhibitors suppress chronic lymphocytic leukemia B-cell activation and migration. Leukemia. 2012 Jul
26(7):1576-83. [Content Brief]

Last Update2025-04-01 14:45:47
MedChemExpress (MCE) also provides

Thalidomide-4-O-C2-NH2

Category: Signaling Pathways
CAS: 2341840-99-9
Last Update: 2025-04-01 14:45:47

PPARα-MO-1

Category: Signaling Pathways
CAS: 810677-36-2
Last Update: 2025-04-01 14:45:47

Netupitant N-oxide

Category: Signaling Pathways
CAS: 910808-11-6
Last Update: 2025-04-01 14:45:47

MK-0812

Category: Signaling Pathways
CAS: 624733-88-6
Last Update: 2025-04-01 14:45:47

TS-011

Category: Signaling Pathways
CAS: 339071-18-0
Last Update: 2025-04-01 14:45:47

SCH 530348 sulfate

Category: Signaling Pathways
CAS: 705260-08-8
Last Update: 2025-04-01 14:45:47

BAG 956

Category: Signaling Pathways
CAS: 853910-02-8
Last Update: 2025-04-01 14:45:47

YM758

Category: Signaling Pathways
CAS: 312752-85-5
Last Update: 2025-04-01 14:45:47
  • Home
  • Product Category

© 2015 ChemBK.com All Rights Reserved | Build: 20150530002