BMS-477118 hydrate MedChemExpress (MCE)

Product Name	Saxagliptin monohydrate
Synonyms	CS-1180 BMS477118 hydrate BMS 477118 hydrate Saxagliptin hydrate Saxagliptin monohydrate Saxagliptin hydrate Unii-9gb927lajw (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrate Synonyms CS-1180 BMS477118 hydrate BMS 477118 hydrate Saxagliptin hydrate Saxagliptin monohydrate Saxagliptin hydrate Unii-9gb927lajw (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.13,7]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrate (1s,3s,5s)-2-((2s)-2-amino-2-(3-hydroxytricyclo(3.3.1.13,7)dec-1-yl)acetyl)-2-azabicyclo(3.1.0)hexane-3-carbonitrile hydrate Saxagliptin hydrate (1S,3S,5S)-2-[(2S)-2-Amino-2-(3-hydroxytricyclo[3.3.1.1(3,7)]dec-1-yl)acetyl]-2-azabicyclo[3.1.0]hexane-3-carbonitrile hydrate
CAS	945667-22-1
EINECS	641-082-3
Chemical Formula	C18H27N3O3
Molecular Weight	333.43
inchi	InChI:1S/C18H25N3O2.H2O/c19-8-13-2-12-3-14(12)21(13)16(22)15(20)17-4-10-1-11(5-17)7-18(23,6-10)9-17;/h10-15,23H,1-7,9,20H2;1H2
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Saxagliptin hydrate Saxagliptin hydrate MedChemExpress (MCE) HY-10285A 945667-22-1 BMS-477118 hydrate 98.13% -20°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months Descriptions Saxagliptin hydrate Saxagliptin hydrate MedChemExpress (MCE) HY-10285A 945667-22-1 BMS-477118 hydrate 98.13% -20°C, protect from light, stored under nitrogen In solvent : -80°C, 6 months -20°C, 1 month (protect from light, stored under nitrogen) Room temperature in continental US may vary elsewhere. Saxagliptin hydrate (BMS-477118 hydrate) is a potent, selective, reversible, competitive and orally active dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM) inhibitor. Saxagliptin hydrate has the peotential for type 2 diabetes mellitus research. Saxagliptin (100 nM 48 hours INS-1 832/13 cells) treatment significantly induceS β-cell proliferation[1]. Saxagliptin (100 nM 48 hours INS-1 832/13 cells) treatment increases the p-AKT and active β-catenin protein levels, paralleled with the increase of c-myc and cyclin D1 protein expression[1]. Saxagliptin acts by preventing the degradation of glucagon-like peptide-1 and hence increases secretion of insulin and decreases secretion of glucagon[3]. Saxagliptin (1 mg/kg for 12 weeks) treatment in high-fat diet/streptozotocin-induced diabetic rats, significant improvement in pancreas insulin secretion capacity evaluated by hyperglycemia clamp and increased β-cell to α-cell areas ratio are observed[1]. Saxagliptin dose-dependently inhibits plasma DPP-4 activity in Han-Wistar rats, by ~70% at 7 hours postdose with 1 mg/kg and by ~90% at 7 hours postdose with 10 mg/kg. At 24 hours postdose, ~20% and 70% inhibition, respectively, remained[2]. DPP-4 \| \| \| \| \| \| \| \| \| \| [1]. Chun-Jun Li, et al. Saxagliptin Induces β-Cell Proliferation through Increasing Stromal Cell-Derived Factor-1α In Vivo and In Vitro. Front Endocrinol (Lausanne). 2017 Nov 27 8:326. [Content Brief] [2]. Darshan J Dave. Saxagliptin: A dipeptidyl peptidase-4 inhibitor in the treatment of type 2 diabetes mellitus. J Pharmacol Pharmacother. 2011 Oct 2(4):230-5. [Content Brief] [3]. Carolyn F Deacon, et al. Saxagliptin: a new dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes. Adv Ther. 2009 May 26(5):488-99. [Content Brief]
Last Update	2025-04-01 14:45:47

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