MK2-IN-1 MedChemExpress (MCE)

Product Name	MK2-IN-1
Synonyms	CS-2121;MK2-IN-1;MK2-IN-1 (MK2 Inhibitor);2-Furancarboxamide, 5-(4-chlorophenyl)-N-[4-(1-piperazinyl)phenyl]-N-(2-pyridinylmethyl)-
CAS	1314118-92-7
EINECS
Chemical Formula	C27H25ClN4O2
Molecular Weight	472.97
inchi
Package	5 mg;10 mg
Price	Email to quote
Descriptions	MK2-IN-1 MK2-IN-1 MedChemExpress (MCE) HY-12834 1314118-92-7 99.04% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions MK2-IN-1 MK2-IN-1 MedChemExpress (MCE) HY-12834 1314118-92-7 99.04% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. MK2-IN-1 (compound 1) is a potent and selecitve MAPKAPK2 (MK2) inhibitor with an IC50 of 0.11 uM for MK2 and an EC50 of 0.35 uM for pHSP27. MK2-IN-1 impaires the phosphorylation level of serine residues in the Tfcp2l1 protein. MK2-IN-1 (purchased from MCE 5 μM 0.5-8 h) gradually increases Tfcp2l1 protein level without a change in the Tfcp2l1 transcript level within 2 h[2]. MK2-IN-1 induces more alkaline phosphatase (AP)-positive colonies than the other factors in a short time[2]. \| \| \| \| \| \| \| \| \| \| [1]. Rao AU, et al. Facile synthesis of tetracyclic azepine and oxazocine derivatives and their potential as MAPKAP-K2 (MK2) inhibitors. Bioorg Med Chem Lett. 2012 Jan 15 22(2):1068-72. [Content Brief] [2]. Yan Zhang, et al. MK2 promotes Tfcp2l1 degradation via β-TrCP ubiquitin ligase to regulate mouse embryonic stem cell self-renewal. Cell Rep. 2021 Nov 2 37(5):109949. [Content Brief]
Last Update	2025-04-01 14:45:47

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