PTK 0796; Amadacycline MedChemExpress (MCE)

Product Name	Amadacycline
Synonyms	PTK-796 PTK 0796 PTK0796 PTK 0796 PTK-0796 OMADACYCLINE OMadacycline Synonyms PTK-796 PTK 0796 PTK0796 PTK 0796 PTK-0796 OMADACYCLINE OMadacycline Amadacycline AMadacycline Omadacycline AMADACYCLINE Omadacycline-D9 2-Naphthacenecarboxamide 4,7-bis(dimethylamino)-9-[[(2,2-dimethylpropyl)amino]methyl]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)- 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-9-[[(2,2-dimethylpropyl)amino]methyl]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-
CAS	389139-89-3
EINECS
Chemical Formula	C29H40N4O7
Molecular Weight	556.65
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	Omadacycline Omadacycline MedChemExpress (MCE) HY-14865 389139-89-3 PTK 0796 Descriptions Omadacycline Omadacycline MedChemExpress (MCE) HY-14865 389139-89-3 PTK 0796 Amadacycline 99.85% -20°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture and light) Room temperature in continental US may vary elsewhere. Omadacycline (PTK 0796), a first-in-class orally active aminomethylcycline antibacterial, is a member of the tetracycline class of antibiotics. Omadacycline acts through the inhibition of bacterial protein synthesis by binding to the 30S ribosomal subunit. Omadacycline possesses broad-spectrum antibacterial activity against aerobic and anaerobic Gram-positive and Gram-negative bacteria, as well as atypical bacteria. Omadacycline can be used for the research of acute bacterial skin and skin-structure infections, community-acquired pneumonia, and urinary tract infections. Omadacycline displays activity against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), beta-hemolytic streptococci, penicillin-resistant Streptococcus pneumonia (PRSP) and Haemophilus influenzae (H. influenzae), with MIC90s of 1.0, 0.25, 0.5, 0.25 and 2.0 μg/mL respectively[2]. Omadacycline is active against strains expressing tetracycline and other antibiotics resistance by ribosomal protection and active tetracycline efflux[2]. Omadacycline (0.11-18 mg/kg a single i.v.) exhibits efficacy against Streptococcus pneumonia, Escherichia coli, and Staphylococcus aureus in mice systemic infection model, with ED50s ranging from 0.30 mg/kg to 3.39 mg/kg[2]. Tetracycline \| \| \| \| \| \| \| \| \| \| [1]. Durães F, et, al. Omadacycline: A Newly Approved Antibacterial from the Class of Tetracyclines. Pharmaceuticals (Basel). 2019 Apr 21 12(2):63. [Content Brief]* [2]. Macone AB, et, al. In vitro and in vivo antibacterial activities of omadacycline, a novel aminomethylcycline. Antimicrob Agents Chemother. 2014 58(2):1127-35. [Content Brief] [3]. Zhanel GG, et, al. Omadacycline: A Novel Oral and Intravenous Aminomethylcycline Antibiotic Agent. Drugs. 2020 Feb 80(3):285-313. [Content Brief] [4]. Markham A, et, al. Omadacycline: First Global Approval. Drugs. 2018 Dec 78(18):1931-1937. [Content Brief]
Last Update	2025-04-01 14:45:47

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