NSC 23766 MedChemExpress (MCE)

Product Name	NSC 23766 TETRAHYDROCHLORIDE
Synonyms	CS-594 CS-1187 NSC23766 NSC 23766 NSC-23766 free base NSC 23766 TETRAHYDROCHLORIDE N6-[2-(4-Diethylamino-1-methylbutylamino)-6-methylpyrimidin-4-yl]-2-methylquinoline-4,6-diamine tetrahydrochloride Synonyms CS-594 CS-1187 NSC23766 NSC 23766 NSC-23766 free base NSC 23766 TETRAHYDROCHLORIDE N6-[2-(4-Diethylamino-1-methylbutylamino)-6-methylpyrimidin-4-yl]-2-methylquinoline-4,6-diamine tetrahydrochloride N6-[2-[[4-(DIETHYLAMINO)-1-METHYLBUTYL]AMINO]-6-METHYL-4-PYRIMIDINYL]-2-METHYL-4,6-QUINOLINEDIAMINE TRIHYDROCHLORIDE
CAS	733767-34-5
EINECS
Chemical Formula	C24H35N7
Molecular Weight	421.58
inchi
Package	10 mM * 1 mL;5 mg;10 mg;50 mg
Price	Email to quote
Descriptions	NSC 23766 NSC 23766 MedChemExpress (MCE) HY-15723 733767-34-5 99.74% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions NSC 23766 NSC 23766 MedChemExpress (MCE) HY-15723 733767-34-5 99.74% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. NSC 23766 is a cell-permeable, reversible and specific inhibitor of Rac GTPase, used for cancer treatment. NSC 23766 (100 μM) treatment effectively inhibits polar body emission in a dose-dependent manner. NSC 23766 (200 μM) increases the percentage of morphologically abnormal spindles of oocytes. In NSC 23766-treated oocytes, the p-MAPK protein expression is significantly decreased[2]. NSC23766 (50 μM) plus 100 ng/mL Jagged1, GDF9 and BMP15, reduces the number of germLine cell cysts and increases the number of primordial follicles[3]. NSC23766 significantly inhibits GTP-Rac1 activity and phosphorylation of Rac1-PAK, ERKs and p38 MAPK in the spinal dorsal horn neurons[4]. NSC23766 (2.5 mg/kg/day, i.p.) significantly attenuates the onset of spontaneous diabetes in NOD mice, without significant effects on the growth (body weights) of the mice. NSC23766 significantly increases the expression of Rac1 and CHOP, a marker for ER-stress, in islets from NOD mice[1]. Balb/c control and NOD mice are at 7 weeks of age and are divided into four groups (n=8/group). At 8 weeks of age two groups of experimental animals (Balb/c and NOD) receive NSC23766 (2.5 mg/kg/day, i.p./daily) and other two groups, which serve as control Balb/c and NOD mice and receive equal volume of saline. The body weights and blood glucose are monitored every week for 34 weeks. Briefly, fresh spinal cord tissue of the lumbar enlargement is homogenised in the presence of protease and phosphatase inhibitors and lysed with buffer. After being centrifuged at 12,000× g for 5 min at 4°C, the supernatants are collected and incubated with PAK-PBD beads at 4°C on a rotator for 1 h and then the beads are pelleted through centrifugation at 5000× g for 3 min at 4°C. The resulting pellet is resuspended in LaemmLi buffer and boiled for 2 min. The bead samples are subjected to Western blot analysis. Total Rac1 in each sample is also determined by Western blot analysis. \| \| \| \| \| \| \| \| \| \| [1]. Veluthakal R, et al. NSC23766, a Known Inhibitor of Tiam1-Rac1 Signaling Module, Prevents the Onset of Type 1 Diabetes in the NOD Mouse Model. Cell Physiol Biochem. 2016 39(2):760-7. [Content Brief] [2]. Song SJ, et al. Inhibition of Rac1 GTPase activity affects porcine oocyte maturation and early embryo development. Sci Rep. 2016 Oct 3 6:34415 [Content Brief] [3]. Zhao L, et al. Rac1 modulates the formation of primordial follicles by facilitating STAT3-directed Jagged1, GDF9 and BMP15 transcription in mice. Sci Rep. 2016 Apr 6 6:23972 [Content Brief] [4]. Wang Y, et al. Involvement of Rac1 signalling pathway in the development and maintenance of acute inflammatory pain induced by bee venom injection. Br J Pharmacol. 2016 Mar 173(5):937-50 [Content Brief]
Last Update	2025-04-01 14:45:47

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