Diclofenac MedChemExpress (MCE)

Product Name	Diclofenac Potassium
Synonyms	ProSorb Diclofenac Potassium PotassiuM diclofenac Diclofenic potassiuM DICLOFENAC POTASSIUM DICLOFENAC POTASSIUM SALT POTASSIUM [2-[(2,6-DICHLOROPHENYL)AMINO]PHENYL]ACETATE Synonyms ProSorb Diclofenac Potassium PotassiuM diclofenac Diclofenic potassiuM DICLOFENAC POTASSIUM DICLOFENAC POTASSIUM SALT POTASSIUM [2-[(2,6-DICHLOROPHENYL)AMINO]PHENYL]ACETATE potassium 2-(2-(2,6-dichlorophenylamino)phenyl)acetate potassium {2-[(2,6-dichlorophenyl)amino]phenyl}acetate 2[(2,6-dichlorophenyl)amino]benzeneacetic acid potassium salt 2-[(2,6-dichlorophenyl)amino]benzeneacetic acid potassium salt
CAS	15307-81-0
EINECS	630-422-6
Chemical Formula	C14H10Cl2KNO2
Molecular Weight	334.24
inchi	InChI=1/C14H11Cl2NO2.K/c15-10-5-3-6-11(16)14(10)17-12-7-2-1-4-9(12)8-13(18)19;/h1-7,17H,8H2,(H,18,19);/q;+1/p-1
Package	10 mM * 1 mL;10 mg;25 mg;50 mg;100 mg;500 mg
Price	Email to quote
Descriptions	Diclofenac potassium Diclofenac potassium MedChemExpress (MCE) HY-15038 15307-81-0 99.99% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Diclofenac potassium Diclofenac potassium MedChemExpress (MCE) HY-15038 15307-81-0 99.99% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Diclofenac potassium is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac potassium induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade. Diclofenac effectively blocks COX-1 mediated prostanoid production from U937 cell microsomes, with an IC50 of 7±3 nM[1]. Diclofenac (1-60 μM 1 day) induces neural stem cells (NSCs) death in a concentration-dependent manner[3]. Diclofenac (10-60 μM 6 hours) increases the expression of cleaved (activated) caspase-3[3]. Diclofenac (3 mg/kg, b.i.d., for 5 days) significantly increases faecal 51Cr excretion in rats, and such effect is also observed in squirrel monkeys after administrated of 1 mg/kg twice daily for 4 days[1]. Diclofenac (10 mg/kg administered via oral route just prior to induction of inflammation) shows in vivo anti-inflammatory activity in Wistar rats[1]. Human COX-2 1.3 nM (IC50, in CHO cells) Human COX-1 4 nM (IC50, in CHO cells) Ovine COX-2 0.84 nM (IC50) Ovine COX-1 5.1 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May 121(1):105-17. [Content Brief] [2]. Labib MB, et al. Design, synthesis of novel isoindoline hybrids as COX-2 inhibitors: Anti-inflammatory, analgesic activities and docking study. Bioorg Chem. 2018 Oct 80:70-80. [Content Brief] [3]. Chiho Kudo, et al. Diclofenac Inhibits Proliferation and Differentiation of Neural Stem Cells. Biochem Pharmacol. 2003 Jul 15 66(2):289-95. [Content Brief]
Last Update	2025-04-01 14:45:47

MedChemExpress (MCE) also provides

Thalidomide-4-O-C2-NH2

Category: Signaling Pathways
CAS: 2341840-99-9
Last Update: 2025-04-01 14:45:47

PPARα-MO-1

Category: Signaling Pathways
CAS: 810677-36-2
Last Update: 2025-04-01 14:45:47

Netupitant N-oxide

Category: Signaling Pathways
CAS: 910808-11-6
Last Update: 2025-04-01 14:45:47

MK-0812

Category: Signaling Pathways
CAS: 624733-88-6
Last Update: 2025-04-01 14:45:47

TS-011

Category: Signaling Pathways
CAS: 339071-18-0
Last Update: 2025-04-01 14:45:47

SCH 530348 sulfate

Category: Signaling Pathways
CAS: 705260-08-8
Last Update: 2025-04-01 14:45:47

BAG 956

Category: Signaling Pathways
CAS: 853910-02-8
Last Update: 2025-04-01 14:45:47

YM758

Category: Signaling Pathways
CAS: 312752-85-5
Last Update: 2025-04-01 14:45:47


Supplier Name	MedChemExpress (MCE)
Contact	sales
Tel	609-228-6898
Mobile	609-228-6898
QQ
Email	sales@medchemexpress.com; tech@medchemexpress.com
Website	https://www.medchemexpress.com/
Wechat

Request for quotation

Supplier Contact