HIV-1 integrase inhibitor 8 MedChemExpress (MCE)

Product Name	SPIROBIINDANE
Synonyms	SPIROBIINDANE 3,3,3',3'-Tetramethyl-1,1'-spirobi[indan]-6,6'-diol tetrahydrotetramethyl-1,1'-spirobi-1H-indene-6,6'-diol 6,6'-Dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindan 6,6'-Dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindane Synonyms SPIROBIINDANE 3,3,3',3'-Tetramethyl-1,1'-spirobi[indan]-6,6'-diol tetrahydrotetramethyl-1,1'-spirobi-1H-indene-6,6'-diol 6,6'-Dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindan 6,6'-Dihydroxy-3,3,3',3'-tetramethyl-1,1'-spirobiindane 3,3,3',3'-Tetramethyl-2,2',3,3'-tetrahydro-1,1'-spirobi[1H-indene]-6,6'-diol 3,3,3',3'-Tetramethyl-2,2',3,3'-tetrahydro[1,1'-spirobi[1H-indene]]-6,6'-diol 2,2'',3,3''-TETRAHYDRO-3,3,3'',3''-TETRAMETHYL-1,1''-SPIROBI-1H-INDENE- 6,6''-DIOL
CAS	1568-80-5
EINECS
Chemical Formula	C21H24O2
Molecular Weight	308.41
inchi
Package	10 mM * 1 mL;50 mg;100 mg
Price	Email to quote
Descriptions	HIV-1 integrase inhibitor 8 HIV-1 integrase inhibitor 8 MedChemExpress (MCE) HY-107485 1568-80-5 99.88% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions HIV-1 integrase inhibitor 8 HIV-1 integrase inhibitor 8 MedChemExpress (MCE) HY-107485 1568-80-5 99.88% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. HIV-1 integrase inhibitor 8 is a HIV-1 integrase inhibitor, compound 8. HIV-1 integrase inhibitor 8 is against 3′-processing (TC) and strand-transfer (ST) activities in the presence of Mn2+ as the cationic cofactor by gel assay with IC50 values of 275 µM and 200 µM, respectively. It inhibits the strand-transfer (ST) activity with an IC50 value of 200 µM[1].The DNA relaxation activity of MCV topoisomerase is monitored by gel electrophoresis, while DNA cleavage and religation activities were monitored using a microtiter assay. HIV-1 integrase inhibitor 8 inhibits MCV topoisomerase and DNA religation with IC50 values of 500 µM and 200 µM, respectively. This result demonstrates that compound 8 is inactive against topoisomerase in both assays[1]. HIV-1 integrase inhibitor 8 induces cell cytotoxicity and yields a LD50 (dose at which the signal is reduced 50% due to cell death) of 20 μM in HeLa cells[1]. \| \| \| \| \| \| \| \| \| \| [1]. Molteni, et al. A New Class of HIV-1 Integrase Inhibitors: The 3,3,3', 3'-tetramethyl-1,1'-spirobi(indan)-5,5',6,6'-tetrol Family.J Med Chem [Content Brief]
Last Update	2025-04-01 14:45:47

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