Chlorpyrifos MedChemExpress (MCE)

Product Name	chlorpyrifos
Synonyms	ISO BSI ANSI Eradex OMS 971 DURSBAN Lorsban Synonyms ISO BSI ANSI Eradex OMS 971 DURSBAN Lorsban Dowco179 ENT27311 DOWCO 179 DURSBAN(R) dursban hf Clorpyrifos CHLORPYRIFOS chlorpyrifos Chlorpyritos Chlorpyriphos Trichlorpyrphos chlorpyrifos-ethyl O,O-diethyl O-3,5,6-trichloro-2-pyridyl phosphorothioate O,O-diethyl S-(3,5,6-trichloropyridin-2-yl) thiophosphate O,O-diethyl-O-(3,5,6-trichloro-2-pyridyl)phos-phorothioate O,O-diethyl O-(3,5,6-trichloropyridin-2-yl) phosphorothioate Phosphorothioic acid O,O-diethyl O-(3,5,6-trichloro-2-pyridinyl) ester
CAS	2921-88-2
EINECS	220-864-4
Chemical Formula	C9H11Cl3NO3PS
Molecular Weight	350.59
inchi	InChI=1/C9H11Cl3NO3PS/c1-3-15-17(14,16-4-2)18-9-7(11)5-6(10)8(12)13-9/h5H,3-4H2,1-2H3
Package	10 mM * 1 mL;50 mg;100 mg
Price	Email to quote
Descriptions	Chlorpyrifos Chlorpyrifos MedChemExpress (MCE) HY-B0815 2921-88-2 99.94% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months Descriptions Chlorpyrifos Chlorpyrifos MedChemExpress (MCE) HY-B0815 2921-88-2 99.94% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Chlorpyrifos is a neurotoxic insecticide that belongs to the class of thionite esters. Chlorpyrifos is also a AChE inhibitor that affects neurological function in insects, humans and other animals. Chlorpyrifos interferes with cell replication and differentiation, ultimately altering synaptic transmission in neurons. Chlorpyrifos mediates desulfuration to produce chlorpyrifos oxon (CPO), which has higher affinity toward the active site of serine-dependent ester hydrolases such as AChE[2]. Chlorpyrifos (3.9-250 μM 24-72 h) is toxic to oligodendrocyte progenitors[3]. Chlorpyrifos toxicity is associated with (7.5-480 μM 18 h) nuclear condensation and elevation of caspase 3/7 activity, (60 μM 2, 4 h) Heme oxygenase-1 mRNA expression in Central Glia (CG-4) cells, and (30, 60, 120 μM 24 h) enhances H2DCF-DA intensity[3]. Chlorpyrifos (97-276 mg/kg p.o. single dose) has moderately acute oral toxicity, with lethal dose, 50% (LD50) of 97-276 mg/kg in rats[2]. Chlorpyrifos (1 mg/kg and 5 mg/kg for 1 mL/kg s.c. once daily for 3 d) has adverse effect on learning and memory abilities of rats, and affects pregnant rats on gestational days 9-12, results offspring behavioral abnormalities[4]. AChE \| \| \| \| \| \| \| \| \| \| [1]. Silva MH. Effects of low-dose chlorpyrifos on neurobehavior and potential mechanisms: A review of studies in rodents, zebrafish, and Caenorhabditis elegans. Birth Defects Res. 2020 Apr 1 112(6):445-479. [Content Brief] [2]. Choi K, et al. Metabolism of chlorpyrifos and chlorpyrifos oxon by human hepatocytes. J Biochem Mol Toxicol. 2006 20(6):279-91. [Content Brief] [3]. Saulsbury MD, et al. Chlorpyrifos induces oxidative stress in oligodendrocyte progenitor cells. Toxicology. 2009 May 2 259(1-2):1-9. [Content Brief] [4]. Icenogle LM, et al. Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation. Neurotoxicol Teratol. 2004 Jan-Feb 26(1):95-101. [Content Brief]
Last Update	2025-04-01 14:45:47

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