6-Azathymine MedChemExpress (MCE)

Product Name	6-methyl-1,2,4-triazine-3,5-diol
Synonyms	NSC 3426 NSC 38620 AI3-50849 USAF CB-28 CCRIS 3440 Azathymine 6-AZATHYMINE Synonyms NSC 3426 NSC 38620 AI3-50849 USAF CB-28 CCRIS 3440 Azathymine 6-AZATHYMINE 6-Azathymine 6-AZA-5-METHYLURACIL 5-Methyl-6-azauracil 6-METHYL-S-TRIAZINE-3,5-DIONE 6-Methyl-as-triazine-3,5-diol 6-methyl-1,2,4-triazine-3,5-diol 6-Methyl-1,2,4-triazine-3,5-diol 6-Methyl-1,2,4-triazine-3,5-dione 3,5-DIHYDROXY-6-METHYL-1,2,4-TRIAZINE 3,5-Dihydroxy-6-methyl-1,2,4-triazine 6-Methyl-as-triazine-3,5-(2H,4H)-dione as-Triazine-3,5(2H,4H)-dione, 6-methyl- 6-AZA-2,4-DIHYDROXY-5-METHYL-PYRIMIDINE 6-METHYL-1,2,4-TRIAZINE-3,5(2H,4H)-DIONE 6-Methyl-1,2,4-triazine-3,5(2H,4H)-dione 1,2,4-Triazine-3,5(2H,4H)-dione,6-methyl- 1,2,4-TRIAZINE-3,5(2H,4H)-DIONE, 6-METHYL- 1,2,4-Triazine-3,5(2H,4H)-dione, 6-methyl- (9CI)
CAS	932-53-6
EINECS	213-253-9
Chemical Formula	C4H5N3O2
Molecular Weight	127.1
inchi	InChI=1/C4H7N3O2/c1-2-3(8)5-4(9)7-6-2/h2,6H,1H3,(H2,5,7,8,9)
Package	10 mM * 1 mL;100 mg;250 mg;500 mg
Price	Email to quote
Descriptions	6-Azathymine 6-Azathymine MedChemExpress (MCE) HY-136559 932-53-6 99.94% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions 6-Azathymine 6-Azathymine MedChemExpress (MCE) HY-136559 932-53-6 99.94% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. 6-Azathymine, a 6-nitrogen analog of thymine, is a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor. 6-Azathymine inhibits the biosynthesis of DNA, and has antibacterial and antiviral activities. 6-Azathymine is a competitive antagonist of the growth of Streptococcus faecalis (8043) and several other strains of microorganisms. Studies of the mechanism of action of 6-Azathymine reveal that S. faecalis can convert the analog to the corresponding deoxyriboside, azathymidine[2]. The administration of 6-Azathymine to the mouse leads to the urinary elimination not only of free Azathymine, but also of various metabolites of it. Following the administration of 6-Azathymine-5-14C to mice, radioactivity is found in all tissues investigated, not only in the form of free Azathymine, but also as metabolic derivatives[3]. \| \| \| \| \| \| \| \| \| \| [1]. N Tamaki, et al. Purification, Characterization and Inhibition of D-3-aminoisobutyrate Aminotransferase From the Rat Liver. Eur J Biochem. 1990 Apr 20 189(1):39-45. [Content Brief] [2]. W H PRUSOFF, et al. Effect of the Deoxyriboside of 6-azathymine (Azathymidine) on the Biosynthesis of Deoxyribonucleic Acid by Bone Marrow and Neoplastic Cells (In Vitro). Biochim Biophys Acta. 1956 Apr 20(1):209-14. [Content Brief] [3]. R A GAITO, et al. Studies on the Metabolism of Thymine and 6-azathymine. Biochem Pharmacol. Apr-May 1962 11:323-36. [Content Brief] [4]. B. Gabrielsen, et al. In vitro and in vivo antiviral (RNA) evaluation of orotidine 51-monophosphatedecarboxylase inhibitors and analogues including 6-azauridine-51-(ethylmethoxyalaninyl)phosphate (a 51-monophosphate prodrug). Antiviral Chemistry & Chemotherapy (1994) 5(4), 209-220.
Supplier Website	https://www.medchemexpress.com/6-azathymine.html
Last Update	2025-05-21 16:50:25

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