Oxatomide MedChemExpress (MCE)

Product Name	Oxatomide
Synonyms	tinset;Dasten;Cobiona;Celtect;Oxatomide;oxatomida;1-[3-[4-(DIPHENYLMETHYL)-1-PIPERAZINYL]PROPYL]-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE
CAS	60607-34-3
EINECS	262-320-9
Chemical Formula	C27H30N4O
Molecular Weight	426.55
inchi
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	Oxatomide Oxatomide MedChemExpress (MCE) HY-123205 60607-34-3 99.56% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Oxatomide Oxatomide MedChemExpress (MCE) HY-123205 60607-34-3 99.56% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Oxatomide is a potent and orally active dual H1-histamine receptor and P2X7 receptor antagonist with antihistamine and anti-allergic activity. Oxatomide almost completely blocks the ATP-induced current in human P2X7 receptors (IC50 of 0.95 μM). Oxatomide inhibits ATP-induced Ca2+ influx with an IC50 value of 0.43 μM and also inhibits serotonin. H1 Receptor P2X7 Receptor serotonin \| \| \| \| \| \| \| \| \| \| [1]. Kazuki Yoshida, et al. P2X7 receptor antagonist activity of the anti-allergic agent oxatomide. Eur J Pharmacol. 2015 Nov 15 767:41-51. [Content Brief] [2]. K Ohmori, et al. Pharmacological studies on oxatomide (KW-4354). (7) Antagonistic effects on chemical mediators. Nihon Yakurigaku Zasshi. 1983 May 81(5):399-409. [Content Brief]
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