Pramipexole dihydrochloride MedChemExpress (MCE)

Product Name	Pramipexole
Synonyms	Mirapex Pramipexole Mirapex,Sifrol,Mirapexin pramipexole hydrochloride Pramipexole dihydrochloride monohydrate (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride monohydrate Synonyms Mirapex Pramipexole Mirapex,Sifrol,Mirapexin pramipexole hydrochloride Pramipexole dihydrochloride monohydrate (S)-2-Amino-4,5,6,7-tetrahydro-6-(propylamino)benzothiazole dihydrochloride monohydrate (6S)-N'-Propyl-4,5,6,7-tetrahydro-1,3-benzothiazole-2,6-diamine hydrate dihydrochloride (S)-2-Amino-6-(propylamino)-4,5,6,7-tetrahydrobenzothiazol2HClH2Otetrahydrobenzothiazol 2,6-Benzothiazolediamine, 4,5,6,7-tetrahydro-N6-propyl-, dihydrochloride, monohydrate, (6S)-
CAS	191217-81-9
EINECS	687-708-9
Chemical Formula	C10H19Cl2N3S
Molecular Weight	284.249
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Package	10 mM * 1 mL;5 mg;10 mg;50 mg
Price	Email to quote
Descriptions	Pramipexole dihydrochloride hydrate Pramipexole dihydrochloride hydrate MedChemExpress (MCE) HY-B0410A 191217-81-9 98.0% Store at room temperature, keep dry and cool In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions Pramipexole dihydrochloride hydrate Pramipexole dihydrochloride hydrate MedChemExpress (MCE) HY-B0410A 191217-81-9 98.0% Store at room temperature, keep dry and cool In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. Pramipexole dihydrochloride hydrate is a selective and blood-brain barrier (BBB) penetrant dopamine D2-type receptor agonist, with Kis of 2.2 nM, 3.9 nM, 0.5 nM and 1.3 nM for D2-type receptor, D2, D3 and D4 receptors, respectively. Pramipexole dihydrochloride hydrate can be used for the research of Parkinson's disease (PD) and restless legs syndrome (RLS). Pramipexole dihydrochloride hydrate shows a low binding affinity for D1-type receptor, with an IC50 of >50,000 nM[1]. Pramipexole dihydrochloride hydrate (0.01-10 μM 72 hours) produces dose-dependent increases of dendritic arborization and soma size[3]. Pramipexole dihydrochloride hydrate attenuates levodopa-induced toxicity in mesencephalic cultures[4]. Pramipexole dihydrochloride hydrate (0.25-1 mg/kg i.p.) significantly reduces the infarction volume in animals[5]. Pramipexole dihydrochloride hydrate improves neurological recovery[5]. Pramipexole dihydrochloride hydrate prevents ischemic cell death via mitochondrial pathways in ischemic stroke[5]. D2 Receptor 3.9 nM (Ki) D3 Receptor 0.5 nM (Ki) D4 Receptor 1.3 nM (Ki) \| \| \| \| \| \| \| \| \| \| [1]. Kvernmo, T., et al. A review of the receptor-binding and pharmacokinetic properties of dopamine agonists. Clin Ther, 2006. 28(8): p. 1065-78. [Content Brief] [2]. Takashi Okura, et al. Blood-brain barrier transport of pramipexole, a dopamine D2 agonist. Life Sci. 2007 Apr 3 80(17):1564-71. [Content Brief] [3]. Ginetta Collo, et al. Ropinirole and Pramipexole Promote Structural Plasticity in Human iPSC-Derived Dopaminergic Neurons via BDNF and mTOR Signaling. Neural Plast. 2018 2018: 4196961. [Content Brief] [4]. P M Carvey, et al. Attenuation of levodopa-induced toxicity in mesencephalic cultures by pramipexole. J Neural Transm (Vienna). 1997 104(2-3):209-28. [Content Brief] [5]. Syed Suhail Andrabi, et al. Pramipexole prevents ischemic cell death via mitochondrial pathways in ischemic stroke. Dis Model Mech. 2019 Aug 1 12(8): dmm033860. [Content Brief]
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Last Update	2025-05-21 16:50:25

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