FCE 26743 mesylate; EMD 1195686 mesylate MedChemExpress (MCE)

Product Name	2(S)-[4-(3-Fluorobenzyloxy)benzylamino]propionamide methanesulfonate
Synonyms	NW-1015 NW 1015 FCE-26743 PNU 151774E PNU-151774E FCE-28073(R-isomer) Safinamide mesylate Synonyms NW-1015 NW 1015 FCE-26743 PNU 151774E PNU-151774E FCE-28073(R-isomer) Safinamide mesylate Safinamide mesilate EMD 1195686 Mesylate PNU-151774E,FCE28073 SafinaMide Methanesulfonate (S)-(+)-2-[[4-(3-Fluorobenzoxy)benzyl]amino]propanamide N~2~-{4-[(3-fluorobenzyl)oxy]benzyl}-D-alaninamide methanesulfonate 2(S)-[4-(3-Fluorobenzyloxy)benzylamino]propionamide methanesulfonate (S)-2-[[4-[(3-Fluorobenzyl)oxy]benzyl]amino]propanamide methanesulfonate
CAS	202825-46-5
EINECS
Chemical Formula	C17H19FN2O2.CH4O3S
Molecular Weight	398.4490232
inchi	InChI=1/C17H19FN2O2.CH4O3S/c1-12(17(19)21)20-10-13-5-7-16(8-6-13)22-11-14-3-2-4-15(18)9-14;1-5(2,3)4/h2-9,12,20H,10-11H2,1H3,(H2,19,21);1H3,(H,2,3,4)/t12-;/m1./s1
Package	10 mM * 1 mL;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Safinamide mesylate Safinamide mesylate MedChemExpress (MCE) HY-70057A 202825-46-5 FCE 26743 mesylate Descriptions Safinamide mesylate Safinamide mesylate MedChemExpress (MCE) HY-70057A 202825-46-5 FCE 26743 mesylate EMD 1195686 mesylate 99.87% 4°C, sealed storage, away from moisture In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture) Room temperature in continental US may vary elsewhere. Safinamide (FCE 26743 EMD 1195686) mesylate is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 μM) over MAO-A (IC50=580 nM). Safinamide mesylate also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8?μM) than at resting (IC50=262?μM) potentials. Safinamide mesylate has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke et.al. Safinamide mesylate (1-300?μM) reduces the amplitude of the peak sodium currents in a concentration-dependent manner.?When currents are stimulated to a?Vtest?of +10 mV from a?Vh?of -110 mV, the IC50?value was 262?μM. When the holding potential is depolarized to -53 mV, the inhibitory effect of Safinamide mesylate with a lower IC50?value (8?μM) in rat cortical neurons[1]. Safinamide mesylate (intraperitoneal?injection 90 mg/kg once daily 14 days) treatment prior to MCAO significantly ameliorates MCAO-caused cerebral infarction volume, neurological deficit, disruption of the brain-blood barrier (BBB), and impairs expression of tight junction protein occludin and ZO-1 in mice[3].Safinamide mesylate (intraperitoneal?injection 5 mg/kg, 15 mg/kg and 30 mg/kg) dose dependently inhibits the veratridine-induced GABA release and Glu release in vivo. At the dose 30 mg/kg, ?Safinamide mesylate prevents the effect of veratridine both on Glu (treatment?F1,8=1.31 time×treatment interaction?F8,64=2.4) and GABA (treatment?F1,8=4.04 time?F8,64=3.76, time×treatment interaction?F8,64=2.83) release.Safinamide mesylate causes a slight, albeit not significant, reduction of veratridine-stimulated Glu release at 0.5 mg/kg and full inhibition at 5 and 15 mg/kg in rat[3]. MAO-B 98 nM (IC50) MAO-A 580 nM (IC50) \| \| \| \| \| \| \| \| \| \| [1]. Leonetti F, et al. Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of type B monoamine oxidase. J Med Chem, 2007, 50(20), 4909-4916. [Content Brief]* [2]. C Caccia, et al.Safinamide: from molecular targets to a new anti-Parkinson drug. Neurology. 2006 Oct 10 67(7 Suppl 2):S18-23. [Content Brief] [3]. Michele Morari, et al. Safinamide Differentially Modulates In Vivo Glutamate and GABA Release in the Rat Hippocampus and Basal Ganglia.J Pharmacol Exp Ther. 2018 Feb 364(2):198-206. [Content Brief]
Last Update	2025-04-01 14:45:47

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