VU0238441 MedChemExpress (MCE)

Product Name	VU0238441
Synonyms	VU0238441 7-Chloro-1-(4-(trifluoromethyl)benzyl)indoline-2,3-dione 7-chloro-1-[[4-(trifluoromethyl)phenyl]methyl]indole-2,3-dione 7-Chloro-1-[[4-(trifluoromethyl)phenyl]methyl]-1H-indole-2,3-dione Synonyms VU0238441 7-Chloro-1-(4-(trifluoromethyl)benzyl)indoline-2,3-dione 7-chloro-1-[[4-(trifluoromethyl)phenyl]methyl]indole-2,3-dione 7-Chloro-1-[[4-(trifluoromethyl)phenyl]methyl]-1H-indole-2,3-dione 1H-Indole-2,3-dione, 7-chloro-1-[[4-(trifluoroMethyl)phenyl]Methyl]-
CAS	85511-68-8
EINECS
Chemical Formula	C16H9ClF3NO2
Molecular Weight	339.7
inchi
Package	1 mg;10 mg;25 mg;50 mg;100 mg;200 mg
Price	Email to quote
Descriptions	VU0238441 VU0238441 MedChemExpress (MCE) HY-12158 85511-68-8 99.88% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions VU0238441 VU0238441 MedChemExpress (MCE) HY-12158 85511-68-8 99.88% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. VU0238441 is a pan muscarinic acetylcholine receptor (mAChR) positive allosteric modulator (PAM) with EC50s of 3.2 μM, 2.8 μM, 2.2 μM, 2.1 μM, >10 μM for M1, M2, M3, M5 and M4, respectively. VU0238441 is an analogue of VU0119498[2]. EC50: 3.2 μM (M1), 2.8 μM (M2), 2.2 μM (M3), 2.1 μM (M5) and >10 μM (M4)[1] In Vitro VU0238441 is an analogue of VU0119498[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> VU0238441 Related Antibodies \| \| \| \| \| \| \| \| \| \| [1]. Thomas M Bridges, et al. Chemical lead optimization of a pan G(q) mAChR M(1), M(3), M(5) positive allosteric modulator (PAM) lead. Part I: Development of the first highly selective M(5) PAM. Bioorg Med Chem Lett. 2010 Jan 15 20(2):558-62. [Content Brief] [2]. Thomas M Bridges, et al. Discovery of the first highly M5-preferring muscarinic acetylcholine receptor ligand, an M5 positive allosteric modulator derived from a series of 5-trifluoromethoxy N-benzyl isatins. J Med Chem. 2009 Jun 11 52(11):3445-8. [Content Brief]
Supplier Website	https://www.medchemexpress.com/vu0238441.html
Last Update	2025-05-21 16:50:25

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