3-Chlorodiphenylamine MedChemExpress (MCE)

Product Name	3-Chlorodiphenylamine
Synonyms	3-CHLORODIPHENYLAMINE 3-Chlorodiphenylamine 3-Chlorodiphenyl ether 3-chloro-N-phenylaniline Diphenylamine, 3-chloro- 3-Chloro-N-phenylaniline n-(3-chlorophenyl)aniline Synonyms 3-CHLORODIPHENYLAMINE 3-Chlorodiphenylamine 3-Chlorodiphenyl ether 3-chloro-N-phenylaniline Diphenylamine, 3-chloro- 3-Chloro-N-phenylaniline n-(3-chlorophenyl)aniline 3-Chloro-N-phenyl-benzenamine Benzenamine, 3-chloro-N-phenyl- N-(3-Chlorophenyl)-N-phenylamine
CAS	101-17-7
EINECS	202-922-0
Chemical Formula	C12H10ClN
Molecular Weight	203.67
inchi	InChI=1/C12H10ClN/c13-10-5-4-8-12(9-10)14-11-6-2-1-3-7-11/h1-9,14H
Package	10 mM * 1 mL;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	3-Chlorodiphenylamine 3-Chlorodiphenylamine MedChemExpress (MCE) HY-131948 101-17-7 98.74% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions 3-Chlorodiphenylamine 3-Chlorodiphenylamine MedChemExpress (MCE) HY-131948 101-17-7 98.74% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. 3-Chlorodiphenylamine is a high affinity Ca2+ sensitizer of cardiac muscle. 3-Chlorodiphenylamine is based on diphenylamine and binds to the isolated N-domain of cardiac troponin C (cTnC) (Kd=6 µM). 3-Chlorodiphenylamine is an excellent starting scaffold for the development of more potent Ca2+-sensitizing compounds due to its small size, and can be used for systolic heart failure research. 3-Chlorodiphenylamine is able to bind highly (Kd=10 µM) to a chimeric protein consisting of the regulatory N-domain of cTnC (cNTnC) and the switch region of cTnI (cNTnC–cSp chimera)[1].3-Chlorodiphenylamine (100 µM) results in a 1.5-fold increase in the Ca2+ sensitivity of force development without altering the maximal or resting forces in skinned ventricular trabeculae[1].3-Chlorodiphenylamine (25-100 µM) increases Ca2+ sensitivity of the N-domain of intact cTnC after reconstitution into the cTn complex (cTnC complexed with cTnI and cTnT) in a concentration-dependent manner. It exhibits pCa50s with 6.39±0.01, 6.65±0.01, and 6.73±0.02 in the presence of 25, 50, and 100 µM 3-Chlorodiphenylamine, respectively[1]. Kd: 6 µM (N-domain of cardiac troponin C (cTnC))Kd: 10 µM (cNTnC–cSp chimera)[1] In Vitro 3-Chlorodiphenylamine is able to bind highly (Kd=10 µM) to a chimeric protein consisting of the regulatory N-domain of cTnC (cNTnC) and the switch region of cTnI (cNTnC–cSp chimera)[1].3-Chlorodiphenylamine (100 µM) results in a 1.5-fold increase in the Ca2+ sensitivity of force development without altering the maximal or resting forces in skinned ventricular trabeculae[1].3-Chlorodiphenylamine (25-100 µM) increases Ca2+ sensitivity of the N-domain of intact cTnC after reconstitution into the cTn complex (cTnC complexed with cTnI and cTnT) in a concentration-dependent manner. It exhibits pCa50s with 6.39±0.01, 6.65±0.01, and 6.73±0.02 in the presence of 25, 50, and 100 µM 3-Chlorodiphenylamine, respectively[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> 3-Chlorodiphenylamine Related Antibodies \| \| \| \| \| \| \| \| \| \| [1]. Svetlana B Tikunova, et al. 3-Chlorodiphenylamine activates cardiac troponin by a mechanism distinct from bepridil or TFP. J Gen Physiol. 2019 Jan 7 151(1):9-17. [Content Brief]
Last Update	2025-04-01 14:45:47

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