BCH001 MedChemExpress (MCE)

Product Name	2-((3-(ethoxycarbonyl)-6-(trifluoromethoxy)quinolin-4-yl)amino)benzoic acid
Synonyms	BCH001;2-((3-(ethoxycarbonyl)-6-(trifluoromethoxy)quinolin-4-yl)amino)benzoic acid;3-Quinolinecarboxylic acid, 4-[(2-carboxyphenyl)amino]-6-(trifluoromethoxy)-, 3-ethyl ester
CAS	384859-58-9
EINECS
Chemical Formula	C20H15F3N2O5
Molecular Weight	420.34
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	BCH001 BCH001 MedChemExpress (MCE) HY-137817 384859-58-9 98.83% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US Descriptions BCH001 BCH001 MedChemExpress (MCE) HY-137817 384859-58-9 98.83% Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year Room temperature in continental US may vary elsewhere. BCH001, a quinoline derivative, is a specific PAPD5 inhibitor. BCH001 restores telomerase activity and telomere length in dyskeratosis congenita (DC) induced pluripotent stem cells. BCH001 shows no inhibition of poly(A)-specific ribonuclease (PARN) or several other canonical and non-canonical polynucleotide polymerases. BCH001 is used to regulate aging. BCH001 (100 nM-1 µM for 7 days) reduces telomerase RNA component (TERC) RNA oligo-adenylation and increases steady state TERC RNA levels in PARN-mutant iPSC clones. BCH001 causes few transcriptome-wide changes and rescues other ncRNAs disrupted by PARN mutations[1]. BCH001 (1 µM, 24-72 h) has no adverse impact on cell growth, cell cycle, or apoptosis in induced pluripotent stem cells (iPSCs) from DC[1]. BCH001 inhibits ATP- and dose-dependently recombinant PAPD5 (rPAPD5) in vitro. PAPD5 is a non-canonical polymerase that oligoadenylates and destabilizes telomerase RNA component (TERC)[1]. \| \| \| \| \| \| \| \| \| \| [1]. Neha Nagpal, et al. Small-Molecule PAPD5 Inhibitors Restore Telomerase Activity in Patient Stem Cells. Cell Stem Cell. 2020 Jun 4 26(6):896-909.e8. [Content Brief]
Last Update	2025-04-01 14:45:47

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