CD73-IN-4 MedChemExpress (MCE)

Product Name	1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 6-chloro-N-cyclopentyl-1-[5-O-(phosphonomethyl)-β-D-ribofuranosyl]-
Synonyms	CD73-IN-4;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 6-chloro-N-cyclopentyl-1-[5-O-(phosphonomethyl)-β-D-ribofuranosyl]-
CAS	2216764-29-1
EINECS
Chemical Formula	C16H23ClN5O7P
Molecular Weight	463.81
inchi
Package	10 mM * 1 mL;1 mg;10 mg
Price	Email to quote
Descriptions	CD73-IN-4 CD73-IN-4 MedChemExpress (MCE) HY-131967 2216764-29-1 99.21% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions CD73-IN-4 CD73-IN-4 MedChemExpress (MCE) HY-131967 2216764-29-1 99.21% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor, with an IC50 of 2.6 nM for human CD73. CD73-IN-4 is potential for the research of cancer immunology. CD73-IN-4 (compound 4a) exhibits excellent potency against soluble hCD73 (IC50 = 0.86 nM) and soluble mouse CD73 (mCD73 IC50 = 3.0 nM), CHO cells overexpressing hCD73 (IC50 = 2.6 nM) or mCD73 (IC50 = 13 nM), and the human ovary cancer cell line SKOV-3 (IC50 = 0.55 nM). It exhibits excellent selectivity (IC50 > 10?000 nM) against CD39, A2aR, and NTPDase2, 3, and 8[1]. CD73[1] In Vitro CD73-IN-4 (compound 4a) exhibits excellent potency against soluble hCD73 (IC50 = 0.86 nM) and soluble mouse CD73 (mCD73 IC50 = 3.0 nM), CHO cells overexpressing hCD73 (IC50 = 2.6 nM) or mCD73 (IC50 = 13 nM), and the human ovary cancer cell line SKOV-3 (IC50 = 0.55 nM). It exhibits excellent selectivity (IC50 > 10?000 nM) against CD39, A2aR, and NTPDase2, 3, and 8[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> CD73-IN-4 Related Antibodies \| \| \| \| \| \| \| \| \| \| [1]. Ehesan U Sharif , et al. Discovery of Potent and Selective Methylenephosphonic Acid CD73 Inhibitors. J Med Chem. 2021 Jan 5. [Content Brief]
Last Update	2025-04-01 14:45:47

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