PD-1/PD-L1-IN-8 MedChemExpress (MCE)

Product Name	3-Pyrrolidinecarboxylic acid, 1-[[7-cyano-2-[3'-[[3-[[(3R)-3-hydroxy-1-pyrrolidinyl]methyl]-1,7-naphthyridin-8-yl]amino]-2,2'-dimethyl[1,1'-biphenyl]-3-yl]-5-benzoxazolyl]methyl]-, (3R)-
Synonyms	INCB084550;3-Pyrrolidinecarboxylic acid, 1-[[7-cyano-2-[3'-[[3-[[(3R)-3-hydroxy-1-pyrrolidinyl]methyl]-1,7-naphthyridin-8-yl]amino]-2,2'-dimethyl[1,1'-biphenyl]-3-yl]-5-benzoxazolyl]methyl]-, (3R)-
CAS	2230911-59-6
EINECS
Chemical Formula	C41H39N7O4
Molecular Weight	693.79
inchi
Package	1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	INCB086550 INCB086550 MedChemExpress (MCE) HY-134884 2230911-59-6 PD-1/PD-L1-IN-8 99.80% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions INCB086550 INCB086550 MedChemExpress (MCE) HY-134884 2230911-59-6 PD-1/PD-L1-IN-8 99.80% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. INCB086550 is a potent, oral, small-molecule PD-L1 inhibitor with IC50s value of 3.1, 4.9 and 1.9 nM for human, cynomolgus, and rat, respectively. INCB086550 promotes the dimerization of cell-surface PD-L1 and induces PD-L1 entry into Golgi vesicles then traffick to the nucleus. INCB086550 can be used for multiple cancers research. INCB086550 (0.1-10000 nM, 20 h) has no overt toxicity to pleural effusion fluids cells[1]. INCB086550 (1 µmol/L, 24 h) induces the dimerization of cell-surface PD-L1 and resulting in internalization[1]. INCB086550 (15, 200 mg/kg for Oral gavage, once or twice) inhibits greater than 90% of unoccupied cell surface PD-L1 in MDA-MB-231 mice model[1]. INCB086550 (2, 20, or 200 mg/kg for Oral gavage, b.i.d) inhibits tumor growth in MC38 huPD-L1 mice model[1]. \| \| \| \| \| \| \| \| \| \| [1]. WU LIANGXING, et al. BENZOOXAZOLE DERIVATIVES AS IMMUNOMODULATORS. WO2018119266A1. [2]. Koblish HK, et al. Characterization of INCB086550: A Potent and Novel Small-Molecule PD-L1 Inhibitor. Cancer Discov. 2022 Jun 2 12(6):1482-1499. [Content Brief]
Last Update	2025-04-01 14:45:47

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