WSB1 Degrader 1 MedChemExpress (MCE)

Product Name	WSB1 Degrader 1
Synonyms	WSB1 Degrader 1;2-Pyridinamine, 5,6-bis(4-methoxy-3-methylphenyl)-
CAS	2306039-66-5
EINECS
Chemical Formula	C21H22N2O2
Molecular Weight	334.41
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	WSB1 Degrader 1 WSB1 Degrader 1 MedChemExpress (MCE) HY-141482 2306039-66-5 99.81% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions WSB1 Degrader 1 WSB1 Degrader 1 MedChemExpress (MCE) HY-141482 2306039-66-5 99.81% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. WSB1 Degrader 1 is a poten and orally active WSB1 (WD repeat and SOCS box-containing 1) degrader. WSB1 Degrader 1 has anticancer metastatic effects. WSB1 Degrader 1 (compound 4 0.25-2500 nM 2-24 hours H1299-WSB1 cells) treatment indues WSB1 degradation in time-dependent and dose-dependent manners[1]. WSB1 Degrader 1 (compound 4) exhibits potent antimigration efficacy in both KHOS and H460 cell lines with IC50 values of 39.1 μM and 24.47 μM, respectively[1]. WSB1 Degrader 1 (compound 4) significantly inhibits cancer cell migration under normoxia and hypoxia in KHOS cells. WSB1 Degrader 1 (5 μM) treatment elevates the levels of the RhoGDI2 protein in KHOS cells under hypoxia[1]. The wound-healing of H1299-WSB1 cells is significantly inhibited by treating with WSB1 Degrader 1. WSB1 Degrader 1 can only block the wound-healing capability of wild-type A2780 (A2780-WT) cells but not the A2780-WSB1/KO cells[1]. WSB1 Degrader 1 (compound 4 100 mg/kg p.o. daily for 28 days) treatment can effectively inhibit the pulmonary metastasis of cancer cells[1]. In rats, after 100 mg/kg oral dosing or 160 mg/kg intraperitoneal dosing of WSB1 Degrader 1 (compound 4), the two ways of administration are observed with quick absorption (Tmax), but the former dosing displayed a fast clearance (T1/2). Moreover, Cmax and AUC0-t values of WSB1 Degrader 1 in oral or intraperitoneal dosing groups showed acceptable blood exposure[1]. \| \| \| \| \| \| \| \| \| \| [1]. Jinxin Che, et al. Discovery of 5,6-Bis(4-methoxy-3-methylphenyl)pyridin-2-amine as a WSB1 Degrader to Inhibit Cancer Cell Metastasis. J Med Chem. 2021 Jun 1. [Content Brief]
Supplier Website	https://www.medchemexpress.com/wsb1-degrader-1.html
Last Update	2025-05-21 16:50:25

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