Adraxone MedChemExpress (MCE)

Product Name	Adrenochrome
Synonyms	Adrenochrome
CAS	54-06-8
EINECS
Chemical Formula	C9H9NO3
Molecular Weight	179.17
inchi
Package	1 mg;5 mg;10 mg
Price	Email to quote
Descriptions	Adrenochrome Adrenochrome MedChemExpress (MCE) HY-116513 54-06-8 Adraxone 98.66% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Adrenochrome Adrenochrome MedChemExpress (MCE) HY-116513 54-06-8 Adraxone 98.66% Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Adrenochrome (Adraxone) is an oxidation product of Epinephrine. Adrenochrome is a potent coronary constricting agent in the rat heart. Adrenochrome can be used for neurological disorder research. Adrenochrome decreases microsomal calcium binding, calcium uptake and Ca2+-stimulated Mg2+-dependent ATPase activities. The inhibitory effect of Adrenochrome on microsomal calcium uptake activity of the isolated membrane is independent of pH (6.0-8.0), calcium concentrations (10-200 μM), protein concentration (0.02-0.10 mg/mL), temperature (25-37 degrees C) and incubation time (2-30 min)[2]. In isolated rat hearts, concentrations of Adrenochrome from 1 to 1000 ng/mL increases coronary pressure in a dose- and time-dependent manner. Furthermore, the degree of constriction by Adrenochrome is dependent on the CaCl2 concentration in the perfusion medium[1]. \| \| \| \| \| \| \| \| \| \| [1]. M Karmazyn,, et al. Adrenochrome-induced coronary artery constriction in the rat heart. J Pharmacol Exp Ther. 1981 Oct 219(1):225-30. [Content Brief] [2]. S Takeo,et al. Effects of adrenochrome on calcium accumulating and adenosine triphosphatase activities of the rat heart microsomes. J Pharmacol Exp Ther. 1980 Sep 214(3):688-93. [Content Brief] [3]. Koji Ueda, et al. Catecholamine oxidation-mediated transcriptional inhibition in Mn neurotoxicity. J Toxicol Sci. 2020 45(10):619-624. [Content Brief]
Last Update	2025-04-01 14:45:47

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