MS37452 MedChemExpress (MCE)

Product Name	1-[4-(2,3-Dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-ethanone
Synonyms	MS37452 1-(2,3-dimethoxybenzoyl)-4-[(3-methylphenoxy)acetyl]piperazine 1-(4-(2,3-Dimethoxybenzoyl)piperazin-1-yl)-2-(m-tolyloxy)ethanone 1-[4-(2,3-Dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-ethanone Synonyms MS37452 1-(2,3-dimethoxybenzoyl)-4-[(3-methylphenoxy)acetyl]piperazine 1-(4-(2,3-Dimethoxybenzoyl)piperazin-1-yl)-2-(m-tolyloxy)ethanone 1-[4-(2,3-Dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-ethanone Ethanone, 1-[4-(2,3-dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-
CAS	423748-02-1
EINECS
Chemical Formula	C22H26N2O5
Molecular Weight	398.45224
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg
Price	Email to quote
Descriptions	MS37452 MS37452 MedChemExpress (MCE) HY-119344 423748-02-1 99.81% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions MS37452 MS37452 MedChemExpress (MCE) HY-119344 423748-02-1 99.81% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. MS37452 is a potent inhibitor of CBX7 chromodomain binding to H3K27me3, with a Kd of 27.7 μM. MS37452 can derepress transcription of polycomb repressive complex target gene p16/CDKN2A by displacing CBX7 binding to the INK4A/ARF locus in prostate cancer cells. MS37452 (125-500 μM 12 hours) significantly increases INK4A/ARF transcript levels up to 25% and 60% for 250 μM and 500 μM, respectively, as compared to the DMSO control[1]. MS37452 (250 μM 2 hours) treats human PC3 prostate cancer cells for 2 hours reducing CBX7 occupancy across the INK4A/ARF locus[1]. MS37452 (200 µM 5 days) combined with doxorubicin results in consistently decreased cell viability compared to DMSO treated and single drug treatment[2]. MS37452 (200 µM 5 days), which is a CBX7 chromodomain inhibitor (CBX7i), in combination with doxorubicin is a novel therapeutic strategy[2]. CBX7[1] In Vitro MS37452 (125-500 μM 12 hours) significantly increases INK4A/ARF transcript levels up to 25% and 60% for 250 μM and 500 μM, respectively, as compared to the DMSO control[1]. MS37452 (250 μM 2 hours) treats human PC3 prostate cancer cells for 2 hours reducing CBX7 occupancy across the INK4A/ARF locus[1]. MS37452 (200 µM 5 days) combined with doxorubicin results in consistently decreased cell viability compared to DMSO treated and single drug treatment[2]. MS37452 (200 µM 5 days), which is a CBX7 chromodomain inhibitor (CBX7i), in combination with doxorubicin is a novel therapeutic strategy[2]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> MS37452 Related Antibodies RT-PCR[1] Cell Line: PC3 cells \| \| \| \| \| \| \| \| \| \| [1]. Ren C, et al. Small-molecule modulators of methyl-lysine binding for the CBX7 chromodomain. Chem Biol. 2015 22(2):161-168. [Content Brief] [2]. Connelly KE, et al. CBX Chromodomain Inhibition Enhances Chemotherapy Response in Glioblastoma Multiforme. Yale J Biol Med. 2016 89(4):431-440.
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Last Update	2025-05-21 16:50:25

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