1-Boc-azetidine-3-carboxylic acid MedChemExpress (MCE)

Product Name	1-N-Boc-3-Azetidinecarboxylic acid
Synonyms	RARECHEM BK PT 0278 Boc-Azetidine-3-Carboxylic acid N-Boc-azetidine-3-carboxylic acid Boc-N-Azetidine-3-carboxylic acid 1-N-Boc-3-Azetidinecarboxylic acid 1-Boc-3-Azetidine-3-carboxylic acid Synonyms RARECHEM BK PT 0278 Boc-Azetidine-3-Carboxylic acid N-Boc-azetidine-3-carboxylic acid Boc-N-Azetidine-3-carboxylic acid 1-N-Boc-3-Azetidinecarboxylic acid 1-Boc-3-Azetidine-3-carboxylic acid 1-(tert-butoxycarbonyl)azetidine-3-carboxylate 1-(t-butyloxycarbonyl)-azetidine-3-carboxylic acid 1-(tert-Butoxycarbonyl)azetidine-3-carboxylic acid 1-(tert-butoxy-oxomethyl)-3-azetidinecarboxylic acid 1,3-Azetidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester 1-(tert-Butoxycarbonyl)azetidine-3-carboxylic acid, 1-(tert-Butoxycarbonyl)azetane-3-carboxylic acid
CAS	142253-55-2
EINECS
Chemical Formula	C9H15NO4
Molecular Weight	201.22
inchi	InChI=1/C9H15NO4/c1-9(2,3)14-8(13)10-4-6(5-10)7(11)12/h6H,4-5H2,1-3H3,(H,11,12)/p-1
Package	1 g;5 g;10 g;25 g
Price	Email to quote
Descriptions	1-Boc-azetidine-3-carboxylic acid 1-Boc-azetidine-3-carboxylic acid MedChemExpress (MCE) HY-40141 142253-55-2 98.0% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions 1-Boc-azetidine-3-carboxylic acid 1-Boc-azetidine-3-carboxylic acid MedChemExpress (MCE) HY-40141 142253-55-2 98.0% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. 1-Boc-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Boc-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2] ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].PROTACs contain two different ligands connected by a linker one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. Non-cleavable Linker \| \| \| \| \| \| \| \| \| \| [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 16(5):315-337. [Content Brief] [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020 27(8):998-985. [Content Brief]
Last Update	2025-04-01 14:45:47

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