BocMPO MedChemExpress (MCE)

Product Name	BMPO
Synonyms	BMPO;MDMUYJRRYYXDLZ-UHFFFAOYSA-N;2H-Pyrrole-2-carboxylic acid, 3,4-dihydro-2-methyl-, 1,1-dimethylethyl ester, 1-oxide
CAS	387334-31-8
EINECS
Chemical Formula	C10H17NO3
Molecular Weight	199.25
inchi
Package	10 mM * 1 mL;1 mg;5 mg;10 mg;25 mg;50 mg
Price	Email to quote
Descriptions	BMPO BMPO MedChemExpress (MCE) HY-121137 387334-31-8 BocMPO 98.36% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months Descriptions BMPO BMPO MedChemExpress (MCE) HY-121137 387334-31-8 BocMPO 98.36% 4°C, sealed storage, away from moisture and light In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture and light) Room temperature in continental US may vary elsewhere. BMPO (BocMPO) is a cell-permeable superior spin trap with favorable chemical and spectroscopic features. BMPO (BocMPO) can be used for detecting thiyl radicals, hydroxyl radicals, superoxide anions and glutathiyl radicals. BMPO is able to trap both ?OH and GS? to form more persistent BMPO/?OH and BMPO/?SG adducts. In addition, the electron spin resonance (ESR) spectra of BMPO-derived adducts exhibit high signal-to-noise ratios in biological systems. For example, the ESR spectrum of the BMPO glutathionyl adduct (BMPO/?SG) does not fully overlap with the spectrum of its hydroxyl adduct. The favorable chemical and spectroscopic features make BMPO ideal for the detection of superoxide anions, hydroxyl and thiyl radicals.[1]The potential toxic effects of the spin trap BMPO is measured by two estimates of cell viability (trypan blue exclusion and colony formation).[3]BMPO has no significant effect on cell viability at 2.5 or 25 mM in CHO cells. However, it leads to a significant increase in the number of cells that are unable to exclude Trypan blue at 50 mM BMPO. BMPO significantly reduces a 30% reduction in colony formation at 25 mM concentration in CHO cells. And, BMPO completely inhibits the colony formation of 9L tumor cells at 50 mM.[3]The cell function (rate of oxygen consumption) is also measured, BMPO (25 mM) significantly reduces the oxygen consumption rates in CHO cells.[3] \| \| \| \| \| \| \| \| \| \| [1]. H Zhao, et al. Synthesis and biochemical applications of a solid cyclic nitrone spin trap: a relatively superior trap for detecting superoxide anions and glutathiyl radicals. Free Radic Biol Med [Content Brief] [2]. Hongtao Zhao, et al. Detection and characterization of the product of hydroethidine and intracellular superoxide by HPLC and limitations of fluorescence. Proc Natl Acad Sci U S A [Content Brief] [3]. Nadeem Khan, et al. Spin traps: in vitro toxicity and stability of radical adducts. Free Radic Biol Med. 2003 Jun 1 34(11):1473-81. [Content Brief]
Last Update	2025-04-01 14:45:47

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