U70226E free base MedChemExpress (MCE)

Product Name	Ibutilide
Synonyms	Corvert U-70226E Ibutilide IBUTILIDE Ibutilida IBUTIBIDE 122647-32-9 (Fumarate) Synonyms Corvert U-70226E Ibutilide IBUTILIDE Ibutilida IBUTIBIDE 122647-32-9 (Fumarate) 4-(N-Ethylheptylamino)-1-(4-methylsulfonylaminophenyl)-1-butanol (±)-N-[4-[4-(Ethylheptylamino)-1-hydroxybutyl]phenyl]methanesulfonamide
CAS	122647-31-8
EINECS
Chemical Formula	C20H36N2O3S
Molecular Weight	384.58
inchi
Package	5 mg;10 mg;25 mg;50 mg;100 mg
Price	Email to quote
Descriptions	Ibutilide Ibutilide MedChemExpress (MCE) HY-B0387A 122647-31-8 U70226E free base 98.98% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions Ibutilide Ibutilide MedChemExpress (MCE) HY-B0387A 122647-31-8 U70226E free base 98.98% Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. Ibutilide (U70226E free base), an action potential-prolonging antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. Ibutilide is a potent IKr blocker with an EC50 value of 20 nM at +20 mV in atrial tumor myocytes (AT-1) cells[1]. Ibutilide blocks IKr in cells expressing HERG+MDR11 to the same extent as cells expressing HERG alone (IC50: 22.5 nM vs 27.4 nM). However, cells expressing MDR17 show a marked resistance to Ibutilide (IC50: 105.3 nM vs 27.4 nM)[2]. Ibutilide prolongs cardiac repolarization in vitro and in vivo[1]. Ibutilide infusions (administered cumulatively in three doses, 0.01, 0.02 and 0.05 mg/kg i.v., each as a 10-min infusion) results in both polymorphic and monomorphic non-sustained ventricular tachycardia[3]. \| \| \| \| \| \| \| \| \| \| [1]. Ibutilide, a methanesulfonanilide antiarrhythmic, is a potent blocker of the rapidly activating delayed rectifier K+ current (IKr) in AT-1 cells. Concentration-, time-, voltage-, and use-dependent effects. Circulation. 1995 Mar 15 91(6):1799-806. [Content Brief] [2]. B F McBride, et al. Influence of the G2677T/C3435T haplotype of MDR1 on P-glycoprotein trafficking and Ibutilide-induced block of HERG. Pharmacogenomics J. 2009 Jun 9(3):194-201. [Content Brief] [3]. S S Chugh, et al. Altered response to Ibutilide in a heart failure model. Cardiovasc Res. 2001 Jan 49(1):94-102. [Content Brief]
Supplier Website	https://www.medchemexpress.com/ibutilide.html
Last Update	2025-04-01 14:45:47

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