IDRA 21 MedChemExpress (MCE)

Product Name	2H-1,2,4-Benzothiadiazine,7-chloro-3,4-dihydro-3-methyl-, 1,1-dioxide
Synonyms	IDRA 21 7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE 7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide Synonyms IDRA 21 7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE 7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide 7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE S,S-DIOXIDE 2H-1,2,4-Benzothiadiazine,7-chloro-3,4-dihydro-3-methyl-, 1,1-dioxide 7-chloro-3-methyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide IDRA 21,7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazineS,S-dioxide
CAS	22503-72-6
EINECS	1592732-453-0
Chemical Formula	C8H9ClN2O2S
Molecular Weight	232.69
inchi
Package	10 mM * 1 mL;25 mg;50 mg;100 mg;200 mg;500 mg
Price	Email to quote
Descriptions	IDRA 21 IDRA 21 MedChemExpress (MCE) HY-101528 22503-72-6 99.33% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US Descriptions IDRA 21 IDRA 21 MedChemExpress (MCE) HY-101528 22503-72-6 99.33% Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Room temperature in continental US may vary elsewhere. IDRA 21 is a positive and orally active modulator of the AMPA receptor. IDRA 21 facilitates excitatory neurotransmission via GluR1/2 receptors. IDRA 21 has the potential for the research of cognitive/memory disorders, including those associated with aging. IDRA 21 (1-300 μM, 30 min) increases hippocampal neurons death in a dose-dependent manner[2]. IDRA 21 (0.15-10 mg/kg, p.o., once every 3 days, 3 weeks) improves delayed matching-to-sample (DMTS) task accuracy in young and aged rhesus monkeys[1]. IDRA 21 (6-24 mg/kg, i.g., once time) increases G41 neuronal injury produced by global ischemia in adult rats[2]. \| \| \| \| \| \| \| \| \| \| [1]. Buccafusco JJ, et al. The effects of IDRA 21, a positive modulator of the AMPA receptor, on delayed matching performance by young and aged rhesus monkeys. Neuropharmacology. 2004 Jan 46(1):10-22. doi: 10.1016/j.neuropharm.2003.07.002. [Content Brief] [2]. Yamada KA, et al. The diazoxide derivative IDRA 21 enhances ischemic hippocampal neuron injury. Ann Neurol. 1998 May 43(5):664-9. [Content Brief]
Last Update	2025-04-01 14:45:47

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